运动和饮食对老年人认知功能的影响及其表观遗传学机制探讨

The Benefits of Exercise and Diet On Cognitive Function in the Elderly with an Emphasis on the Uunderlying Epigenetic Mechanisms

我国正步入老龄化社会,研究如何有效延缓衰老,维护老年人的认知功能已成为当今老年医学亟待解决的问题之一。近年来,生活方式影响老年人认知功能的作用倍受关注。因此,本文综述运动和饮食干预对老年人认知发展的影响,并重点探讨其表观遗传学机理研究进展,有助于今后合理、有效地对认知功能衰退进行干预与研究。未来相关的研究应进一步严格研究设计,拓宽多因素的综合,形成更有解释力的、统一的、完整的理论体系。

The Chinese society is rapidly aging.As a result, curbing the aging process and preventing cognitive decline associated with aging are increasingly important.Life-style change is a method that could achieve such a goal with relatively good reproducibility and low cost. The current study summarizes the benefits of sports and dietary intervention on cognitive function in the elderly , with an emphasis on the underlying epigenetic mechanisms.For future studies, improvement in the following aspects is needed：more rigorous study design and inclusion of multiple factors and their interaction.