摘要
目的:观察火把花根片治疗糖尿病肾病大量蛋白尿患者的临床疗效。方法:选择70例糖尿病肾病患者分为治疗组及对照组各35例。对照组予厄贝沙坦胶囊,治疗组予火把花根片,观察治疗3个月后患者尿蛋白定量(U-TP)、尿微量白蛋白/尿肌酐(尿ACR)、肾功能、脂代谢指标变化,进行统计学分析。结果:治疗3个月后,相比较对照组,治疗组中医临床症状积分、总有效率,差异有显著意义(P<0.01);治疗组及对照组治疗前后,U-TP、尿ACR,差异有统计学意义(P<0.05);治疗组及对照组治疗前后,肌酐(Cr)、尿素氮(BUN)无明显统计学差异(P>0.05);治疗组治疗前后及与对照组相比,脂代谢指标有明显统计学差异(P<0.05);对照组治疗前后,脂代谢指标无明显统计学差异(P>0.05)。结论:火把花根片在治疗糖尿病肾病大量蛋白尿方面可以取得较佳的临床收益,不仅可以降低蛋白尿,而且可以改善血脂代谢。
OBJECTIVE To observe the clinical efficacy of Huoba Huagen tablets in the patients with diabetic nephropathy who suffer massive proteinuria.METHODS 70 cases of diabetic nephropathy patients were divided into treatment group and control group,35 cases in each group.The control group was given with irbesartan capsules while the others used Huoba Huagen tablets.The urinary protein excretion(U-TP),urinary albumin / urine creatinine(urine ACR),renal function,lipid metabolism changes were statistically analyzed after three months.RESULTS After 3 months of treatment,there was significant difference in the clinical symptoms of TCM integration and the total efficiency between the control group and the treatment group(P〈0.01).In the treatment group and control group before and after treatment,there was statistically significant difference in U-TP,urine ACR(P〈0.05).However,there was no significant difference in creatinine(Cr),blood urea nitrogen(BUN) in treatment group and control group before and after treatment,(P〉0.05).In treatment group before and after treatment and compared with the control group,the fat metabolic indicators were statistically significant differences(P〈0.05).In the control group,lipid metabolism showed no significant difference after treatment(P〉0.05).CONCLUSION Huoba Huagen tablets in terms of the treatment of diabetic nephropathy proteinuria can get a better clinical benefit,not only can reduce proteinuria,but also improve lipid metabolism.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2014年第20期1762-1764,共3页
Chinese Journal of Hospital Pharmacy
关键词
火把花根片
糖尿病肾病
大量蛋白尿
Huoba Huagen tablets
diabetic nephropathy
massive proteinuria