无配体碘化亚铜催化杂环硫醇与碘代芳烃的C-S偶联反应研究

Study on Ligand-free CuI-catalyzed C-S Cross-coupling of Heterocyclic Thiols with Aryl Iodides

在120℃DMF溶液中,采用10mol%CuI作催化剂,200mol%Na2CO3作碱进行C-S偶联反应,合成了一系列杂环硫化物。该方法无需任何配体,同时具有经济、高效等特点。产物的结构经1 H NMR、13C NMR、MS和元素分析证实。

The ligand-free copper-catalyzed cross-coupling of heterocyclic thiols with aryl iodides was reported.The reaction was carried out in the presence of 10mol%CuI and 200mol% Na2CO3 in DMF at 120℃.A variety of heterocyclic sulfides were prepared with high selectivity and yield.The CuI catalyst was ligand-free,economical and effective.The structures of the products were characterized by 1 H NMR、13 C NMR、MS and elemental analysis.