期刊文献+

黄药子复方制剂致肝损害33例文献分析 被引量:5

Literature Analysis of 33 Cases of Liver Injury Induced by the Compound Preparation of Dioscorea bulbifera L.
下载PDF
导出
摘要 目的:探讨黄药子复方制剂致肝损害的临床特点和危险因素,为临床合理用药提供参考。方法:以"黄药子"、"黄独"、"肝损害"、"肝损伤"等为检索词,检索中国生物医学文献数据库(CBM)以及万方、维普、知网等中文科技期刊数据库,收集黄药子复方制剂致肝损害的文献进行统计分析。结果:共收集到黄药子复方制剂致肝损害患者33例,其中男性15例(45.45%),女性18例(54.55%);年龄14~69岁,平均(51.39±12.75)岁,≥45岁中老年患者30例(90.91%)。原发疾病为白癜风(7例,占21.12%)、慢性萎缩性胃炎(7例,占21.12%)、良性前列腺增生症(17例,占51.52%)、食管炎(1例,占3.03%)、甲状腺功能亢进症(1例,占3.03%);所用药物分别为白蚀丸、复方黄药子制剂、癃闭舒胶囊、增生平片、兆誉隆抑亢丸。15例可追溯服药时间和发病时间的病例中,服药时间为20~180天(65.87±39.80);发病时间为用药后20~180天(68.47±39.31)。所有病例均为医嘱用药。慢性起病者32例,亚急性起病者1例。临床表现以消化系统症状为主。实验室检查以肝功能指标异常为主,ALT(546.9±156.28 U/L)、AST(367.25±184.79 U/L)、ALP(209.6±93.43 U/L)、DBIL(109.56±93.61μmol/L)、TBIL(164.19±155.8μmol/L)。停药并给予对症治疗后,肝功能恢复,全部治愈。结论:黄药子复方制剂致肝损害发病率较高,以肝功能损害为主,临床上必须谨慎使用黄药子及其复方制剂;确需使用时,必须用前检测肝功能,用后每4周检测1次肝功能,发现肝功能异常及时救治。 Objective : To study the clinical characteristics and the dangerous factors of liver injury induced by the compound preparation of Dioscorea bulbifera L. and to provide reference for rational use of the medicine accordingly. Methods : By searching Chinese Biomedical Database (CBM), Wanfang Data Knowledge Service Platform, Vip Jounal Integration Platform, Chinese Knowledge Resource Integrated Database and other Chinese journal databases with keywords Dioseorea bulbifera L. , liver injury/ disease, etc. to eoUect data from the literature of liver injury induced by the compound preparation, with which statistical analysis was performed. Results: 33cases of liver injuries induced by the compound preparation of Dioscorea bulbifera L. were collected. 15patients (45.45%) of the cases were male and 18 (54. 55% ) were female. The age ranges from 14to 69with the average 51.39~12. 75and 30patients (90.91%) were aged, i. e. older than 45. The primary diseases were leukoderma (7cases, 21.12% ), chronic atrophic gastritis (7cases, 21.12% ), optimum benign prostatic hyperplasia (17cases, 51.52% ), esophagitis ( lcase, 3.03% ), hyperthyroidism ( lcase, 3.03% ) ; the medicines used were respectively Baishi Pill, Compound Huangyaozi Preparation, Longbishu Capsule, Zengshengping Pill, Zhaoyulong Yikang Pill. Duration of taking the medicines and getting the drug-induced diseases of 15cases were traceable; the duration of taking the medicines ranges from 20to 180days (65. 87±39. 80) and the duration of getting the secondary diseases ranges from 20to 180days (68.47±39. 31 ). All patients fol lowed their medical orders. 32cases were chronic and lcase was sub-acute. The clinical manifestation mainly appeared to be gastrointestinal symptoms and the laboratory examination mainly showed abnormal liver function, ALT (546. 9± 156. 28U/L), AST (367.25±184. 79U/L), ALP (209. 6±93.43U/L), DBIL ( 109. 56±93.61μmol/L) and TBIL ( 164. 19± 155.81μmol/L). After drug withdrawal and symptomatic treatment, the liver function became normal and all patients were cured. Conclusion: Liver injury caused by the compound preparation of Dioscorea bulbifera L. has a high morbidity, so it should be used carefully in clinical treatment. Liver function of patients should be examined before the use of the medicine and once every four weeks after, in order to discover abnormal liver function early to apply proper treatment.
出处 《四川中医》 2014年第9期162-164,共3页 Journal of Sichuan of Traditional Chinese Medicine
关键词 黄药子/黄独 复方制剂 肝损害 药物不良反应 药源性疾病 Dioscorea bulbifera L. Compound preparation Liver injury Adverse drug reaction Drug-induced disease
  • 相关文献

参考文献12

二级参考文献48

共引文献101

同被引文献151

引证文献5

二级引证文献33

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部