坦索罗辛与阿呋唑嗪治疗输尿管结石的疗效比较

Comparison of Therapeutic Efficacy of Tamsulosin vs. Alfuzosin in the Treatment of Ureteral Stone

目的：比较坦索罗辛与阿呋唑嗪治疗输尿管结石的疗效。方法：将156例确诊为输尿管结石的患者随机分为试验组与对照组（各78例）,分别给予阿呋唑嗪10 mg、坦索罗辛0.2mg,均为qd,服药2-4周;患者均每日饮水〉2 L,适量运动。比较两组患者的排石率、结石排出时间和药品不良反应发生情况。结果：试验组与对照组的排石率分别为61.5%、83.3%（P〈0.05）,两组患者的结石排出时间和药品不良反应发生率差异无统计学意义（P〉0.05）。结论：坦索罗辛治疗输尿管结石比阿呋唑嗪疗效更好。

OBJECTIVE： To compare the clinical efficacy of tamsulosin vs. alfuzosin in the treatment of ureteral stone.METH- ODS： 156 patients meeting the criteria were randomly assigned into trial group and control group with 78 cases in each group.They were given alfuzosin 10 mg or tamsulosin 0.2 mg respectively, qd, for 2-4 weeks, with moderate exercise.The quantity of water intake in both groups were 〉2 L.The exclusion rate, exclusion time of the ureteral stone and adverse drug reactions were compared between 2 groups.RESULTS： The exclusion rate of 2 groups were 61.5% and 83,3% （P〈0,05） ; there was no significant difference in exclusion time and the incidence of ADR between 2 groups （P〉0.05）. CONCLUSIONS： Tamsulosin is better than alfuzosin in the treatment of ureteral stones.