临床药师参与1例粪肠球菌腹腔感染患者的治疗分析

Analysis of Clinical Pharmacists Participating in the Treatment for a Patient with Abdominal Infection Caused by Enterococcus faecalis

目的:探讨临床药师在参与粪肠球菌腹腔感染患者抗感染治疗中的作用。方法:通过1例粪肠球菌腹腔感染的案例,根据药敏试验给予替考拉宁治疗后,患者感染指标呈下降趋势,但患者反复、间断性发热。临床药师从利奈唑胺与替考拉宁的体内外抗菌活性、临床疗效与组织穿透性方面进行了对比,建议医师将替考拉宁替换为利奈唑胺。患者治疗2 d后,感染得到控制。结果:抗感染取得了良好的效果,患者好转出院。结论:临床药师参与患者抗感染方案制订,可为医师和患者提供更加有效的治疗方案。

OBJECTIVE： To investigate the role of clinical pharmacists in the treatment for patients with Enterococcus faecalis-induced abdominal infection. METHODS： The patient with E. faecalis-induced abdominal infection received teicoplanin based on drug sensitive test; infection indicators declined, but the patient suffered from recurrent and intermittent fever. Clinical pharmacists compared linezolid with teicoplanin in terms of in vitro antibacterial activity, clinical efficacy and tissue penetration, and suggested physicians to use linezolid instead of teicoplanin; two days later, the infection was controlled. RESULTS： Good therapeutic effect had been obtained, and the patient was discharged from the hospital. CONCLUSIONS： The clinical pharmacist who participate in developing anti-infection programs could provide more effective treatment options for physicians and patients.