重度痴呆血清VitB_(12)、叶酸及同型半胱氨酸水平的研究被引量：3

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摘要目的了解血清VitB12、叶酸(FOL)和同型半胱氨酸(Hcy)水平与重度阿尔茨海默病(AD)和血管性痴呆(VaD)的关系。方法以2011年4月—2013年4月期间于浙江省立同德医院和绍兴市第六人民医院老年科住院或门诊的重度AD(54例)和VaD(74例)患者为研究对象;以同期在浙江省立同德医院行健康体检45例健康老年人(CN)作为对照。应用Beckman Coulter Acess全自动微粒化学发光免疫分析系统测定血清VitB12、FOL浓度;应用Hitachi全自动生化分析仪,采用CBS原理测定血清Hcy浓度。应用SPSS 16.0软件进行统计分析。结果AD、VaD血清VitB12、FOL水平较CN低,而Hcy水平高于CN;AD和VaD组间血清VitB12、FOL水平无显著性差异;AD Hcy低于VaD。纵向观察发现:AD在1、6、12月VitB12、FOL逐渐下降趋势,而Hcy水平先降后升;VaD在1、6、12月VitB12、FOL下降趋向,Hcy有波动性。结论重度AD、VaD血清VitB12、FOL水平较CN低,而AD与VaD差异却没有统计学意义;高FOL在VaD的发生发展过程中起着更重要作用。

作者郭忠伟李宝华张江涛吴月静方央俞建洪陈杏丽

机构地区浙江省立同德医院老年科浙江医院老年科浙江省绍兴市第六人民院老年科

出处《中华全科医学》 2014年第12期2037-2039,F0003,共4页 Chinese Journal of General Practice

基金 2013年浙江省医药卫生一般研究计划(2013-KYB065)

关键词阿尔茨海默病血管性痴呆高同型半胱氨酸 B族维生素

分类号 R749.16 [医药卫生—神经病学与精神病学] R446.11 [医药卫生—诊断学]

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