20Hz重复经颅磁刺激治疗改善难治性精神分裂症注意和执行功能的损害

The Effect of 20Hz Repetitive Transcranial Magnetic Stimulation on Attention and Executive Function of Refractory Schizophrenia

目的探讨20Hz高频重复经颅磁刺激(rTMS)治疗对难治性精神分裂症患者认知功能的影响。方法 32例难治性精神分裂症患者随机分为两组,分别接受20Hz高频重复经颅磁刺激治疗(治疗组)与伪刺激治疗(对照组)2周。在治疗前和治疗结束时采用持续操作测验(CPT)和Wisconsin卡片分类测验(WCST)测定患者认知功能。结果 32例患者均完成治疗。治疗后与治疗前相比,CPT各项指标比较差异无显著性;20Hz rTMS对WCST各项指标的影响与空白对照组相比,WCST5(完成的分类数)治疗组治疗后增加,而对照组治疗后降低,两组相比有显著统计学意义(F=6.215,P=0.022)。结论 20Hz高频重复经颅磁刺激治疗可改善难治性精神分裂症患者的执行功能。

Objective To evaluate the effect of 20Hz repetitive Transcranial Magnetic Stimulation （ rTMS） on attention and performance functions in patients with refractory schizophrenia .Methods Thirty-two patients with refractory schizophrenia were randomly assigned to rTMS therapy group （ n=16 ） or sham group （ n=16 ） .Continuous performance test （ CPT ） and Wisconsin Card Sorting Test （WCST）were used to evaluate cognitive function of patients pre and post study .Results There were no differences on CPT between rTMS treatment group and sham pre and post treatment .Compared with sham group ,the rTMS group revealed significant improvements in correct words numbers （F=6.215,P=0.022）.Conclusion Executive function of schizophrenia can be improvement through 20Hz rT-MS treatment .