摘要
目的比较双额与单侧顶颞抽搐电痉挛治疗精神分裂症急性期的效果。方法将58例精神分裂症患者随机分为两组,分别接受双额极(双侧组28人)与单侧非优势半球顶颞极(单侧组30人)抽搐电痉挛治疗。共给予抽搐电痉挛治疗8次,在治疗前、治疗4次、6次、8次时分别给予阳性和阴性症状量表(PANSS)评定临床症状。结果双侧组和单侧组患者治疗前后PANSS评分比较显示,双侧组和单侧组治疗后和治疗前相比,PANSS总分均明显降低,有显著统计学差异(单侧组:t=16.65,P=0.001;双侧组:t=19.84,P=0.001);使用重复测量方差分析比较双侧组和单侧组PANSS量表各因子分的组间差异,结果发现阳性量表评分、一般精神病理量表评分治疗后双侧组降低较单侧组明显,差异存在统计学意义(阳性症状:F=7.87,P=0.01;一般精神病理评分:F=7.74,P=0.01)。以PANSS总分减分率≥75%作为痊愈的标准,双侧组痊愈率明显高于单侧组,差异有统计学意义(χ2=4.86,P=0.04)。在起效时间上,双侧组治疗6次症状改善与单侧组治疗8次改善程度相当,双侧组起效更快。结论双额抽搐电痉挛治疗精神分裂症急性期症状与单侧顶颞相比总体效果相当,治愈率更高,对阳性症状和一般精神病理症状效果更好,起效更快。
Objective To compare the effect of bifrontal and unilateral parieto -temporal modified electroconvulsive therapy on schizophrenia.Methods 58 schizophrenia patients were randomly assigned to bifrontal MECT group （28 cases）and unilateral parieto -temporal MECT group（30 cases）.PANSS were used to eveluate clinical symptom at pre ,4 time point,6 time point,8 time point of MECT.Results The PANSS score decreased significally post treatment both in bifrontal group and unilateral group （ unilateral group：t=16.65,P=0.00;bifrontal group：t=19.84,P=0.00）.The positive symptom score,general psychopathology symptom score decreased significantly in bifrontal group than that in unilateral group （positive score：F=7.87,P=0.01;general psychopathology score：F=7.74, P=0.01）.Regarding the reduction rate of PANSS total score ≥75% as a recovery standard,bifrontal group was significantly higher than unilateral group（χ2 =4.86,P=0.04）.The improvement of symptoms treated 6 times in bifrontal group were the same as that as 8 times improvement in unilateral group .Conclusion The effect of bifrontal MECT is the same as unilateral MECT in the treatment of schizophrenia ,and the cure rate is higher and better for the positive symptoms and general psychopathology symptoms effect .
出处
《中国健康心理学杂志》
2014年第10期1457-1459,共3页
China Journal of Health Psychology
