体位不同对氧化苦参碱注射液抗心绞痛的影响

Pharmacological study of Oxymatrine injection in treatment of angina pectoris

目的:探讨患者不同体位对氧化苦参碱抗心绞痛的临床效果。方法:将诊治的120例心绞痛患者,随机分成12组,每组10例,分别给生理盐水阴性对照组和氧化苦参碱给药组,硝酸甘油、硝酸异山梨酯阳性对照组。分别以站位、卧位、坐位3种不同体位给药,以心电图监测和患者自感症状决定药物效果。结果:经x2检验氧化苦参碱采取抗心绞痛静脉滴注坐位方式效果最好,与其它几种给药体位与药品比较(P﹤0.05)有显著的差异。结论:坐位给药改善心肌缺血效果最明显,患者自感症状良好;站位给药出现体位性低血压,患者出现头晕症状明显;卧位给药患者心脏前后负荷加重,药物治疗效果差,而在3种体位给予氧化苦参碱抗心肌缺血作用优于其他阳性对照组。

Objective：To investigate the clinical pharmacologic actions of Oxymatrine in treatment of angina pectoris. Patient position is different, the effect is different. Methods：120 patients with angina pectoris were randomly divided into 12 groups, each group of 10 cases. To saline negative control group, Oxymatrine administration group, and nitroglycerin and isosorbide dinitrate positive control group, the drug were given at erect position, decubitus position and sitting position. ECG monitoring and patient perceived symptoms were used to determine the effect of the drugs. Results： Through X2 test, the effect of sitting position administration of Oxymatrine was best in the treatment of angina pectoris, and the differences among the three administration routes were significantly dif-ferent （P〈0. 05）. Conclusions：The sitting position administration is the most effective improving myocardial ischemia with good pa-tient perceived symptoms. The erect position administration can cause postural hypotension and the patients feel dizzy. The decubitus position administration＇s effect is worst. By the three administration routes, the effect of Oxymatrine in the treatment of myocardial is-chemia is superior to those of the other positive control groups.