IL-17在乳腺癌中的表达及意义

Expression and significance of IL-17 in breast cancer

目的探讨白细胞介素17(IL-17)在乳腺癌患者血清和T细胞中的表达及与乳腺癌功能指标的相关性。方法采用流式细胞仪分析乳腺癌患者外周血CD3+CD4+IL-17+T细胞百分数;ELISA法测定血清IL-17水平;化学发光免疫分析法检测CA153和CA125的水平,并分析IL-17水平与各指标的相关性。结果乳腺癌患者外周血中CD3+CD4+IL-17+T细胞百分数与健康对照组差异有统计学意义(P<0.05);血清IL-17水平与健康对照组差异有统计学意义(P<0.05);血清IL-17水平与CD3+CD4+IL-17+T细胞百分数及CA153水平均呈正相关;血清IL-17水平与CA125水平无显著相关性。结论 IL-17水平与乳腺癌有关。

Objective To investigate the expression of IL-17 in the serum and T cells of the patients with breast cancer and its correlation with breast cancer functional indicators.Methods The flow cytometry analysis was adopted to detect the percentage of peripheral blood CD3 ＋ CD4 ＋ IL-17 ＋ T cells in breast cancer patients;the ELISA method was used to detect serum IL-17 content;the chemiluminescence immunoassay was used to detect CA153 and CA125 levels.The correlation between IL-17 with various indi-cators was analyzed.Results The percentage of CD3 ＋ CD4 ＋ IL-17 ＋ T cell in peripheral blood of the breast cancer patients had sta-tistically significant difference compared with the healthy control group（P 〈0.05）;serum IL-17 level had statistically significant difference compared with the healthy control group（P 〈0.05）;serum IL-17 level was positively correlated with the percentage of CD3 ＋ CD4 ＋ IL-17 ＋ T cells and the CA153 level;IL-17 level had no significant correlation with serum CA125 level.Conclusion The IL-17 expression level is associated with breast cancer.