慢性肾脏病患者血清PTH和SF检测的临床价值与β_2-MG的相关性研究

Clinical value of detecting serum PTH and SF in patients with chronic kidney disease and their correlation with serum β_2-MG

目的探讨慢性肾脏病(CKD)患者不同时期血清铁蛋白(SF)和甲状旁腺素(PTH)的变化特点与血β2-微球蛋白(β2-MG)的相关性。方法测定不同肾功能时期SF、PTH和β2-MG水平,分别与对照组比较,并将各期SF、PTH和β2-MG水平进行相关性分析。结果代偿组患者SF、PTH和β2-MG水平与对照组比较差异无统计学意义(P>0.05),而失代偿组、肾功能衰竭组和尿毒症组与对照组比较差异有统计学意义(P<0.05)。相关分析显示,145例患者PTH与β2-MG呈正相关(r=0.92,P<0.05),SF与β2-MG亦呈正相关(r=0.92,P<0.05)。结论检测血清PTH、SF及β2-MG水平对了解慢性肾脏病的病情发展和预后判断均有重要的临床价值。

Objective To investigate the change characteristics of serum ferritin（SF）and parathormone （PTH）levels in differ-ent stages of chronic kidney disease（CKD）and their correlation with serum beta 2-microglobulin（β2-MG）.Methods The levels of serum PTH,SF andβ2-MG in different stages of CKD were detected and the detection results were compared with those in the con-trol group.The correlation between serum SF and PTH withβ2-MG in each stage of CKD was analyzed.Results The level of ser-um PTH,SF andβ2-MG in the compensation group had no statistical difference compared with the control group （P 〉0.05）,while which had statistical differences among the decompensation group,renal failure group and uremia group （P 〈0.05）The correlation analysis showed that serum PTH was positively correlated with serumβ2-MG in 145 cases（r=0.92,P 〈0.05）,and the serum SF level was also positively correlated with serumβ2-MG level（r=0.92,P 〈0.05）.Conclusion Detecting serum PTH,SF andβ2-MG levels possesses the important clinical significance for understanding CKD condition and prognosis.