2型糖尿病患者血清甲状腺激素检测的临床意义

Clinical significance of determination of serum thyroid hormone in patient with type 2 diabetes mellitus

目的探讨糖尿病患者血清甲状腺激素相关指标的变化及发生甲状腺功能异常的概率。方法选择86例2型糖尿病患者采用电化学发光法测定其血清FT3、FT4和TSH水平,并选择61例年龄、性别相匹配的健康体检者作为对照组。结果 2型糖尿病患者血清FT3、FT4和TSH水平的检测结果平均值分别为5.09pmol/L、17.32pmol/L和2.81mIU/L。对照组的血清FT3、FT4和TSH水平的平均值分别为4.99pmol/L、17.24pmol/L和2.71mIU/L,糖尿病组同对照组比较,差异无统计学意义(P>0.05)。86例糖尿病组中共有29例患者TSH异常,异常率为33.7%,对照组为14.8%,经χ2检验,差异有统计学意义(P<0.05)。糖尿病患者中,女性的TSH异常率为42.1%,高于糖尿病患者中男性的TSH异常率(17.2%)。结论对糖尿病患者进行血清甲状腺激素的检测十分有必要,尤其是女性患者,以利于早期筛查和防治。

Objective To explore the change of serum thyroid hormone related indicators and the probability of occurrence of thyroid dysfunction abnormality in the patient with type 2 diabetes mellitus（T2DM）.Methods 86 patients with T2DM and 61 age-matched and gender-matched individuals with healthy physical examination as controls were selected and detected serum FT3,FT4 and TSH by the electrochemiluminescence method Results The serum FT3,FT4 and TSH in the T2DM group were 5.09 pmol/L, 17.32 pmol/L and 2.81 mIU/L respectively;which in the normal control group were 4.99 pmol/L,17.24 pmol/L and 2.71 mIU/L respectively,the differences between the two groups had no statistical significance（P 〉0.05）.Among 86 cases of T2DM,29 cases had the serum abnormal TSH with the abnormal rate of 33.7%,which in the control group was 14.8% with statistical difference between the two groups（P 〈0.05）.Among T2DM patients,the TSH abnormal rate of in females was 42.1%,which was higher than 17.2% in males.Conclusion The serum thyroid hormone detection is necessary for the T2DM patients,especially female pa-tients,which is conducive to early screening,prevention and treatment.