育龄期多囊卵巢综合征患者血清自身抗体研究

Study on serum autoantibody in patients with polycystic ovary syndrome in child-bearing period

目的探讨血清非器官特异性自身抗体与多囊卵巢综合征(PCOS)的关系。方法选择就诊于本院的育龄期PCOS患者69例为研究组,同期健康育龄期妇女69例为对照组。采用ELISA法检测血清抗核抗体(ANA)、胶体金斑点渗滤法检测血清抗双縺DNA(ds-DNA)抗体、免疫印迹法检测血清抗可提取性核抗原(ENA)抗体谱。结果研究组与对照组比较,血清中ANA和抗ds-DNA阳性率显著升高,差异有统计学意义(P<0.05),抗ENA自身抗体谱中各种抗体差异无统计学意义(P>0.05)。结论 PCOS患者中存在血清自身抗体阳性。

Objective To investigate the association between serum non-organ-specific autoantibodies and polycystic ovary syn-drome（PCOS）.Methods A total of 69 patients with PCOS in child-bearing period treated in our hospital were selected as the study group and contemporaneous 69 healthy child-bearing year women were selected as the control group.Serum level of antinuclear anti-bodies （ANA）was measured by ELISA,serum level of anti-dsDNA was measured by colloidal gold spot infiltration assay and the extractable nuclear antigen （ENA）auto-antibodies profiles were measured by Western blot.Results Serum levels of ANA and an-ti-dsDNA antibodies in the study group were significantly elevated compared with the control group with statistical difference.Con-clusion Serum autoantibody positive exists in the patients with PCOS.