首钢水钢总医院225例抗菌药物不良反应报告分析

Adverse Drug Reactions of Antibiotics:Analysis of 225 Cases in Shougang Shuigang General Hospital

目的:了解抗菌药物所致药品不良反应(ADR)发生的特点,为临床合理用药提供参考。方法:收集我院2007—2013年收集上报至国家ADR监测网的抗菌药物所致ADR报告225例进行回顾性分析。结果:225例ADR报告中,共涉及7大类27个品种抗菌药物。其中头孢菌素类所致的ADR居首位(44.58%);静脉滴注(97.50%)给药途径最容易引发ADR;ADR累及器官或系统以皮肤及其附件损害最为常见(56.33%)。结论:应重视抗菌药物的合理使用,加强ADR报告和监测工作,以减少ADR的发生,保障患者用药安全。

OBJECTIVE：To investigate the characteristics of antibiotic-induced adverse drug reactions （ADRs） so as to pro-vide reference for clinical rational use of antibiotics. METHODS：A total of 225 ADR cases submitted by our hospital to National ADR Monitoring network during 2007-2013 period were retrospectively analyzed. RESULTS：7 categories and 27 antibiotics were involved in the 225 ADR cases. The ADR cases induced by cephalosporins dominated the first place（44.58%）,induced mostly by drip infusion （97.50%） and manifested mostly as lesions of skin and its appendages （56.33%）. CONCLUSIONS：Great impor-tance should be attached to rational use of antibiotics as well as strengthening ADR reporting and monitoring so as to reduce the oc-currence of ADR and ensure patients’medication safety.