口服华法林的房颤患者冠状动脉造影围术期两种抗凝方案的比较

Comparison of antithrombotic plans in oral warfarin patients with atrial fibrillation during peri-coronary angiography

目的探讨口服华法林的房颤患者行冠状动脉造影术围术期不中断华法林抗凝方案的可行性及安全性。方法选取持续性房颤患者58例，随机分为试验组（不中断华法林）及对照组（中断华法林），比较两组的术前准备时间、术后INR值恢复到2—3的达标时间、围术期出血、血栓栓塞等并发症发生率。结果试验组的术前准备时间、术后INR值恢复到2～3的达标时间比对照组短，差异具有统计学意义（P〈0．05）。两组的出血并发症差异无统计学意义（P〉0．05），两组患者围术期均未发生血栓栓塞并发症。结论口服华法林的房颤患者行冠状动脉造影术，围术期不中断华法林的抗凝方案县寄伞可行的．

Objective To study the feasibility and safety of perioperative antithrombotic plan with non-interruptive warfarin during coronary angiography in oral warfarin patients with atrial fibrillation. Methods A total of 58 patients with persistent atrial fibrillation were randomly divided into trial group （non-interruptive warfarin） and control group（ interruptive warfarin）. The preoperative preparation time, postoperative recovery time （ restored to 2 - 3 ） of international normalized ratio, perioperative bleeding and perioperative embolism were compared between the two groups. Results There were statistically significant differences in preoperative preparation time and postoperative recovery time （ restored to 2 - 3 ） of international normalized ratio between the two groups （P 〈 0.05）. There was no statistically significant difference in perioperative bleeding between the two groups （ P 〉 0.05 ）. No perioperative embolism occurred in both the two groups. Conclusion Perioperative antithrombotic plan with non-interruptive warfa- rin during coronary angiography is safe and effective on oral warfarin patients with atrial fibrillation.