微RNA在胰岛素抵抗中的调节作用

The Regulation Function of miRNAs in Insulin Resistance

微RNA(miRNA)是一类内源性非编码小RNA,通过与靶信使RNA结合而引起其降解或翻译抑制,最终导致靶基因表达受抑,对众多生命过程有重要调控作用。业已发现,在代谢综合征的共同病理基础—胰岛素抵抗(IR)发生进程中,有多种miRNA(Let-7、miRNA-126、miRNA-320等)通过抑制胰岛素受体、胰岛素受体底物、磷脂酰肌醇3-激酶等胰岛素信号转导途径中的分子而参与IR的发生。深入了解miRNA在IR发生中的作用和机制,对于寻找治疗代谢综合征的有效靶点以及预防方法均具有重要意义。

MicroRNAs are a class of endogenous small noncoding RNAs,which combine target mRNAs and then lead to degradation or translational inhibition of target mRNAs.As a result,the expression of target gene is repressed.Therefore,they play a significant role in regulating quite a few biological processes.As far as we know,a number of microRNAs,such as Let-7,miRNA-126,miRNA-320 etc.,participate in the development of insulin resistance,which is the common pathological basis of metabolic syndrome,by inhibiting the molecules in insulin signaling pathways including insulin receptor,insulin receptor substrate,phosphoinositide 3-kinase etc.Thorough understanding of the role and mechanism of microRNAs in the onset of insulin resistance has great significance for finding novel therapeutic targets and preventative methods of metabolic syndrome.