钟样受体4信号通路与非感染性炎症疾病的关系

Relationship between Toll-like Receptor 4 Signaling Path and Non-infectious Inflammation Diseases

钟样受体4(TLR4)是钟样受体家族的成员之一,能识别宿主源性激动剂,在固有免疫和后天免疫中发挥重要作用。近来有研究发现损伤组织释放的自身成分能激活TLR4引起炎性反应,但TLR4信号通路在非感染性炎症发生、发展中的具体作用仍不清楚,如缺血/再灌注、创伤、组织修复与重构和自身免疫疾病等。该文就TLR4信号通路与非感染性炎症性疾病的关系予以综述。

Toll-like receptor 4 （TLR4）,a member of the toll-like receptor family,plays an important role in the activation of the innate immunity and the adaptive immunity by recognizing a wide variety of putative host-derived agonists.Recent studies find that components of injured tissue can activate TLR4 which could result in inflammation.But the specific role of TLR4 signaling path in the initiation and progression of noninfectious inflammatory processes,such as ischemia and reperfusion injury,trauma,tissue repair and regeneration,as well as autoimmune diseases etc.,still remains unclear.Here is to make a review of the relationship between TLR4 signaling path and non-infectious inflammation diseases.