期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

FRAT1与肿瘤的相关性研究进展 被引量：3

Research Progress of FRAT1 and Tumors
下载PDF
导出
摘要 众所周知,癌基因、抑癌基因以及信号转导通路在细胞癌变中起重要作用。Wnt/β-catenin信号转导通路是一个十分保守的信号通路,其靶基因c-myc、cylinD1等与细胞增殖、凋亡调控有关。研究发现,原癌基因FRAT1是Wnt/β-catenin信号通路的正向调节因子,其异常表达与人类多种疾病密切相关。目前研究证实FRAT1的表达与人类多种肿瘤的恶性程度、临床分期及预后相关,研究FRAT1与肿瘤的相关性有望为肿瘤的早期诊断及治疗提供新的潜在靶点。 As is known,oncogenes,anti-oncogene and the signal transduction pathway play important roles in the mechanisms of cell carcinogenesis.Wnt/β-catenin pathway is a highly conserved signal transduction pathway and its target genes are involved in cell proliferation and apoptosis,such as c-myc,cylinDl.FRAT1 has been identified as a positive regulator of the Wnt/β-catenin pathway,and its abnormal expression is closely relatedto human diseases.Meanwhile the present study has confirmed that,FRAT1 expression is associated to human tumor malignant degree,clinical stage and prognosis.Therefore,study on the relationship between FRAT1 and tumor helps to provide a new potential target for early diagnosis and treatment of tumors.
作者 吕婷婷 吕欣 郭庚
机构地区 山西医科大学第一医院消化科 山西医科大学第一医院内分泌科 山西医科大学第一医院神经外科
出处 《医学综述》 2014年第20期3691-3693,共3页 Medical Recapitulate
基金 国家自然科学基金青年基金(81201991) 山西省基础研究计划青年科技研究基金(2012021035-5) 山西省高等学校创新人才支持计划 山西省卫生厅科研课题(201301066)
关键词 FRAT1 WNT/Β-CATENIN信号通路 肿瘤 Frequently rearranged in advanced T cell lymphomas-1 Wnt/β-catenin signal pathway Neoplasms
分类号 R730.3 [医药卫生—肿瘤]
  • 相关文献

参考文献25

  • 1Saitoh T,Mine T,Katoh M.Molecular cloning and expression of proto-oncogene FRAT1 in human cancer[J] .Int J Oncol,2002,20(4):785-789.
  • 2Wang Y,Hewitt SM,Liu S,et al.Tissue microarray analysis of human FRAT1 expression and its correlation with the subcellular localisation of β-catenin in ovarian tumours[J] .Br J Cancer,2006,94(5):686-691.
  • 3Guo G,Liu B,Zhong C,et al.FRAT1 expression and its correlation with pathologic grade,proliferation and apoptosis in human astrocytomas[J] .Med Oncol,2011,28 (1):1-6.
  • 4Saitoh T,Katoh M.FRAT1 and FRAT2,clustered in human chromosome 10q24.1 region,are up-regulated in gastric cancer[J] .Int J Oncol,2001,19(2):311-315.
  • 5Jonkers J,Korswagen HC,Acton D,et al.Activation of a novel proto-oncogene,FRAT1,contributes to progression of mouse T-cell lymphomas[J] .EMBO J,1997,16(3):441-450.
  • 6Yost C,Farr GH 3rd,Pierce SB,et al.GBP,an inhibitor of GSK-3,is implicated in Xenopus development and oncogenesis[J] .Cell,1998,93(6):1031-1041.
  • 7Lee YH,Heo JH,Kim TH,et al.Significance of cell cycle regulatory proteins as malignant and prognostic biomarkers in ovarian epithelial tumors[J] .Int J Gynecol Pathol,2011,30 (3):205-217.
  • 8Van Amerongen R,Nawijn MC,Lambooij JP,et al.Frat oncoproteins act at the crossroad of canonical and noncanonical Wnt-signaling pathways[J] .Oncogene,2010,29(1):93-104.
  • 9Velasco J,Zarrabeitia MT,Prieto JR,et al.Wnt pathway genes in osteoporosis and osteoarthritis:differential expression and genetic association study[J] .Osteoporos Int,2010,21 (1):109-118.
  • 10Jonkers J,Weening JJ,van der Valk M,et al.Overexpression of Frat1 in transgenic mice leads to giomerulosclerosis and nephrotic syndrome,and provides direct evidence for the involvement of FRAT1 in lymphoma progression[J] .Oncogene,1999,18 (44):5982-5990.

二级参考文献64

  • 1DongHongZHAO JianJunHONG ShiYingGUO RunLinYANG JunYUAN ChuanJunWEN KaiYaZHOU ChaoJunLI.Aberrant expression and function of TCF4 in the proliferation of hepatocellular carcinoma cell line BEL-7402[J].Cell Research,2004,14(1):74-80. 被引量：20
  • 2Haeseleer F,Pollet JF,Bollen A,et al. Molecular cloning and sequencing of the attachment site and integrase gene of the temperate mycobacteri- ophage FRAT1 [J]. Nucleic Acids Res, 1992 ;20 ( 6 ) : 1420.
  • 3Hedgepeth CM, Deardorff MA, Rankin K, et al. Regulation of glycogen synthase kinase 3beta and downstream Wnt signaling by axin [J]. Mol Cell Biol, 1999 ; 19 ( 10 ) :7147-57.
  • 4Wang Y,Liu S,Zhu H,et al. FRAT1 overexpression leads to abeirant activation of beta-catenin/TCF pathway in esophageal squamous cell carcinoma[J]. Int J Cancer,2008 ;123(3) :561-8.
  • 5Killick R,Pollard CC, Asuni AA,et al. Presenilin 1 independently regulates beta-catenin stability and transcriptional activity [ J ]. J Biol Chem, 2001 ;276 (5) :48554-61.
  • 6Guo G,Mao X,Wang P,et al. The expression profile of FRATI in human gliomas[J]. Brain Res ,2010 ;1320 : 152-8.
  • 7van Amerongen R, Nawijn MC, Lambooij JP, et al. Frat oncoproteins act at the crossroad of canonical and noncanonical Wnt-signaling pathways [ J]. Oncogene,2010 ;29 ( 1 ) :93-104.
  • 8Hovanes K, Li TW, Munguia JE, et al. Beta-catenin-scnsitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer [J]. Nat Genet,2001 ;28( 1 ) :53-7.
  • 9Boon EM, Keller JJ, Wormhoudt TA, et al. Sulindac targets nuclear betacatenin accumulation and Wnt signalling in adenonms of patients with familial adenomatous polyposis and in human colorectal cancer cell lines [J]. Br J Cancer,2004;90(l):224-9.
  • 10Flora A, Garcia JJ, Thaller C, et al. The E-protein Tcf4 interacts with Mathl to regulate differentiation of a specific subset of neuronal progenitors[J]. Proc Natl Acad Sci USA ,2007 ; 104 (39) :15382-7.

共引文献11

同被引文献14

引证文献3

医学综述
2014年 第20期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部