摘要
肺炎支原体(MP)是儿童呼吸道感染的重要病原体之一,近年来世界各地不断有检出耐大环内酯类抗生素MP的报道,且耐药率不断升高,我国和日本耐药形势严峻。MP耐大环内酯类抗生素的主要机制是23S rRNA V区的基因突变。大环内酯类抗生素仍是MP感染的首选,但对于耐大环内酯类抗生素的MP感染,特别是重症病例,可考虑选择四环素类或喹诺酮类抗生素,但要综合判断、权衡利弊。
Mycoplasma pneumoniae （MP） is a major pathogen in children with respiratory tract infection.The emergence of macrolides resistance in MP strains has been repeatedly reported worldwide in recent years.Moreover,the rates of resistant strains are rising,especially in China and Japan.Mechanism of resistance to macrolides is probably mutation in gene of 23S rRNA Ⅴ region.Macrolides is still the preferred antibiotic of MP infection.Tetracyclines and fluoroquinolones are the drugs of choice for macrolides resistant MP infection,but the replacement should be considered depending on the severity of the disease and possible adverse reaction.
出处
《医学综述》
2014年第20期3736-3738,共3页
Medical Recapitulate
关键词
肺炎支原体
儿童
耐药
抗生素
Mycoplasma pneumoniae
Children
Drug resistance
Antibiotic
