血清维生素D与肿瘤的关系及其检测方法的研究进展

Association between serum vitamin D level and cancer and its detection methods

维生素D是一类甾体化合物,具有多种生物学功能,包括促进小肠对钙和磷的吸收、构建和维持骨质的硬度等。近年的研究发现,维生素D能抑制肿瘤细胞增殖和诱导分化、凋亡以及对某些癌症的发生有预防作用。因此,测定血清维生素D浓度可能对肿瘤的发生和发展判断有帮助。然而,除了乳腺癌外,血清维生素D与肿瘤的关系仍然存在很大的争议,研究结果很不一致,因此仍需进一步深入开展相关探讨。该文就血清维生素D浓度与肿瘤的关系及其检测方法进行综述。

Vitamin D（ VD） is a group of steroid compounds, which plays an important role in a variety of biological functions including promoting the intestinal absorption of calcium and phosphorus, building and maintaining the bone hardness.Recently studies have found that VD exerts cell proliferation inhibition, cell differentiation and apoptosis induction, and chemoprevention properties.Studies showed that there is a clear association between serum VD level and breast cancer.However, in other types of cancer, study results on the relationship between serum VD and cancers are still controversy, inconclusive or contradictory.This article discuss and summarize the relationship between serum VD concentration and cancer and its detection methods.