基于静息态功能磁共振低频振幅算法的创造力脑机制研究

Research on Brain Mechanism of Creativity by Means of Resting-State fMRI Amplitude of Low Frequency Fluctuation Algorithm

创造力是人类特有的一种高级心理活动过程,其神经机制是认知神经科学研究的核心问题。本研究采用比率低频振幅算法(fALFF),在不同的低频频率段(0.01-0.08Hz;slow-5,0.01-0.027Hz;slow-4,0.027-0.073Hz)比较了高低创造力个体的静息态神经活动特征。结果发现,在低频频段(0.01-0.08Hz),高创造力个体的突显网络(salience network,SN)脑区的自发神经波动显著增强,默认网络(default mode network,DMN)脑区的自发神经波动则显著降低。而且fALFF指标具有明显的频带特异性。本研究发现的高创造力个体的自发神经活动模式可能有助于对创造力脑机制的理解,而静息态fALFF技术可以作为一个影像学指标,为创造力脑机制的研究提供新的途径。

Creativity is a high-level mental process that human being is born with exclusively. The neural mechanism of creativity has been a core issue of cognitive neuroscience research. This study applied fractional amplitude of low frequency fluctuation( fALFF),and compared spontaneous neuronal activities in different low frequency sections( 0. 01-0. 08Hz; slow-5,0. 01-0. 027Hz; slow-4,0. 027-0. 073Hz) of the resting state between two groups of subjects. One is highly creative and the other is low in creativity. The results indicated that the high creative group had stronger fALFF in the salience network while the low creative one had stronger fALFF in the default mode network in the section of 0. 01Hz-0. 08 Hz,and fALFF was obviously band specific. The neural activity pattern of high creative persons we found in this study would be of benefit for exploration in creativity neuromechanism,and fALFF as a radiographic index would give a new path to creativity research.