食管癌放疗前后^(18)F-FDGSPECT/CT符合线路显像的临床应用价值

Clinical application value of ^(18)F-FDG SPECT/CT coincidence imaging on esophageal carcinoma patients at pre-and post-radiotherapy

目的研究食管癌放疗前后18F-脱氧葡萄糖(18F-fluorodeoxyglucose,18F-FDG)SPECT/CT符合线路显像的临床应用价值。方法对29例食管癌患者放疗前后行18F-FDG SPECT/CT符合线路显像,必要时放疗靶区根据治疗前18F-FDG SPECT/CT符合线路显像结果进行修正,全部患者均随访12个月并根据临床及影像学随访评价为局部控制或失败,分析肿瘤区域18F-FDG摄取情况的变化及其与疗效的关系。结果 62%(18/29)的患者放疗靶区需根据18F-FDG SPECT/CT符合线路显像结果进行修正,全部患者1年局部控制率为69.0%(20/29),放疗后肿瘤区域18F-FDG摄取明显低于放疗前(P<0.01)。结论 18F-FDG SPECT/CT符合线路显像可用于食管癌放疗靶区的确定、放疗后疗效的预测与随访,且较为经济、简便。

Objective To evaluate the clinical application value of18F-FDG SPECT/CT coincidence imaging on patients with esophageal carcinoma before and after radiotherapy. Methods On 29 patients with esophageal carcinoma,18F-FDG SPECT/CT coincidence imaging was performed before and after radiotherapy. If necessary,the target volume delineation was modified according to the18F-FDG SPECT/CT coincidence imaging before radiotherapy. All of the patients were followed clinically and radiographically for 12 months to assess local control or failure. The correlation between the uptake of18F-FDG in malignant regions and prognosis was analyzed.Results In 18 patients（62%）,the target volume delineation was modified. One year local control rate of all patients was 69.0%（20/29）. There was a significant reduction in the uptake of18F-FDG in malignant regions after radiotherapy（P〈0.01）. Conclusion As a more economical methods,the18F-FDG SPECT/CT coincidence imaging can be used in the target volume delineation before radiotherapy on patients with esophageal carcinoma,predicting their therapy response and following up.