食管癌TNM分期以外的预后因素分析

Prognostic factors in esophageal carcinoma except for TNM staging

目的探讨影响食管癌患者生存的TNM分期以外的主要因素。方法收集1999年12月—2008年03月在安阳市肿瘤医院治疗的2226例食管癌患者的临床资料和随访资料。应用Kaplan-Meier法进行生存分析,组间比较用log-rank检验,多因素分析采用Cox模型分析。结果总的1、3和5年生存率分别为93%、74%和56%。单因素分析表明:年龄、治疗前红细胞计数、治疗前空腹血糖水平、主要治疗手段、肿瘤病理分化程度是食管癌TNM分期以外的预后影响因素。Cox回归分析显示年龄、治疗前红细胞水平和病理分化程度是食管癌的TNM分期以外的独立预后因素。结论年龄、治疗前红细胞水平和病理分化程度是食管癌的TNM分期以外的独立预后因素。

Objective To investigate prognostic factors in esophageal carcinoma except for TNM staging.Methods The data of 2229 patients with esophageal carcinoma who were treated at Anyang tumour hospital from December 1999 to March 2008 were analyzed. The Kaplan-Meier methods was used to analyze prognosis, log-rank test was used to compare the groups,and Cox proporationan hazards model was used for multivariate analysis.Results The 1-,3-,and 5-year survival rates were 93%,74% and 56%,respectively. Based on univariate analysis,age,RBC and level of blood sugar before treatment,methods of treatment,and pathology differention were of prognostic factors. Based on multivariate analysis,the age,RBC before treatment,and pathology differention were of independent factors for prognosis. Conclusions Of all clinical factors except for TNM stage,the age,RBC before treatment,and pathology differentiation are independent factors for prognosis in esophageal carcinoma.