某三级甲等医院2012—2013年度568例药品不良反应报告分析

Analysis of 568 adverse drug reaction reports during 2012 and 2013 at a certain three-level classA hospital

目的综合分析评价某三级甲等医院2012-2013年度药品不良反应(ADR)呈报的基本情况,掌握该院药品不良反应特点、规律和临床表现,为临床合理用药提供依据。方法将ADR报告表填写项目录入Microsoft Excel XP电子表格,根据统计药品ADR发生的患者年龄、ADR表现的分布情况等情况进行归纳分析。结果 568份报告中,其中ADR发生较高的分别是抗菌药物、抗肿瘤、中药注射剂,给药途径以静脉注射引起ADR最为常见,临床表现主要以皮肤及附件损害为主,占33.63%,其次是消化系统,占23.24%。结论临床应加强ADR监测力度,增强ADR呈报意识,提高合理用药水平,保障患者用药安全。

Objective To comprehensively analyze the fundamental state of adverse drug reactions （ADR）reports at a certain three-level classA hospital during 2012 and 2013, to grasp the characteristics, regularity and clinical manifestation of adverse drug reactions, and to pro- vide reference for rational clinical use of drugs.Methods 568 ADR reports were summarized and analyzed.The entry items of ADR reports were put in Microsoft Excel XP spreadsheet and inductively analyzed on the basis of the age of developing ADRs and the distribution of adverse drug reaction manifestation. Results Among the 568 ADR cases, ADR occurred most frequently in patients treated with antibacteri- al drugs, antineoplastic, and traditional Chinese medicine with the administration route of injection.Main clinical manifestations were lesions of skin and its appendants, accounting for 33.63%, and then symptoms of digestive tract accounting for 23.24%.Conclusion ADR monitoring and reporting awareness should be clinical strengthened and the use of drugs should be standardized so as to ensure the safety of drug use.