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胰岛素样生长因子1及其受体与子宫内膜癌的关系研究进展 被引量：5

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摘要 子宫内膜癌是常见的妇科恶性肿瘤,随着对子宫内膜癌分子机制研究的不断深入,针对其发病机制及靶向治疗的研究已成为新的研究热点。研究表明,胰岛素样生长因子-1(Insulin-like growth factor-1,IGF-1)及其受体在子宫内膜癌细胞的恶性表型转化、生长、侵袭及转移等方面具有重要作用。靶向IGF-1/IGF-1R治疗子宫内膜癌可显著抑制子宫内膜癌的增殖和侵袭能力,增强癌细胞对化疗药物的敏感性。因此,将IGF-1/IGF-1R作为子宫内膜癌治疗潜在靶点具有重要的临床意义。
作者 张自辉 叶红
机构地区 三峡大学第一临床医学院
出处 《海南医学》 CAS 2014年第19期2872-2874,共3页 Hainan Medical Journal
基金 湖北省教育厅科学技术研究项目(编号:B2013176)
关键词 胰岛素样生长因子1 子宫内膜癌 靶向治疗
分类号 R737.33 [医药卫生—肿瘤]
  • 相关文献

参考文献17

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二级参考文献28

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共引文献8

同被引文献52

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二级引证文献19

海南医学
2014年 第19期

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