疏肝解郁胶囊联合rTMS治疗冠脉支架植入术后继发焦虑障碍的研究

Study of Shugan Jieyu Capsule Combined with Rtms in the Treatment of Anxiety Disorders after Coronary Stent Implantation

目的:探讨疏肝解郁胶囊合用经颅重复磁刺激法(rTMS)治疗冠脉支架植入术后继发焦虑障碍的疗效。方法:选择2012年6月至2013年12月符合"冠心病"诊断标准、经冠脉支架植入手术并伴发焦虑障碍的患者共120例,随机分为研究组(疏肝解郁胶囊合并rTMS)和对照组(单用疏肝解郁胶囊)各60例。观察时间8周。于治疗前及治疗后2、4、8周采用汉米尔顿焦虑量表(HAMA)、焦虑自评量表(SAS)评定焦虑症状。结果:1两组有效率分别为91.37%和78.18%,经比较有统计学差异(P<0.05);2治疗4、8周后,两组HAMA量表分值比较有统计学差异(P<0.05);3治疗4、8周后,两组SDS量表分值比较有统计学差异(P<0.05);4两组不良反应的发生率分别10.64%和17.78%,经比较无统计学差异(P>0.05)。结论:疏肝解郁胶囊合用rTMS治疗冠脉支架植入术所伴发的焦虑障碍安全有效。

Objective:Shugan Jieyu capsule combined with repetitive transcranial magnetic stimulation(rTMS)therapy after coronary stent implantation with anxiety disorder.Methods:2012June to 2013 December in line with the choice of'criteria for the diagnosis of coronary heart disease by coronary stent implantation operation'and comorbid anxiety disorder,a total of 120 cases,were randomly divided into study group(Shugan Jieyu capsule combined with rTMS)and control group(single with Shugan Jieyu capsule)60cases.The observation time was 8weeks.Before treatment and after treatment in the 2,4,8weeks using the Hamilton Anxiety Scale(HAMA),self rating Anxiety Scale(SAS)assessment of anxiety symptoms.Results:The two groups were 91.37%and 78.18%respectively,compared with statistical significance(P<0.05);2treatment after 4and 8weeks,compared two groups of HAMA scale scores(P<0.05);4,8weeks after treatment,compared two groups of SDS score(P<0.05);the incidence rate of 10.64%and17.78%of the adverse reactions of two groups,the comparison of no statistical significance(P>0.05).Conclusions:Shugan Jieyu capsule combined with rTMS in the treatment of coronary stent implantation is safe and effective with anxiety disorder.