星形细胞上调基因1（AEG －1）介导肿瘤耐药的研究进展

Advances in AEG-1 mediated drug resistance

星形细胞上调基因（Astrosyte elevated gene 1，AEG－1）具有促进癌症发生和发展的作用。AEG－1的过表达与血管生成、转移、及不同组织起源的癌细胞与各种化疗药物耐药有关。研究表明， AEG－1通过Ha－ras、myc、NF－κB及PI3K／Akt信号通路参与经典致癌途径。 AEG－1通过激活AMP激酶来促进自噬作用。另有研究指出， AEG －1调节耐药性是通过多药耐药基因（ Multidrug resistance ， MDR1） mRNA表达增加多聚核糖体的负载量，从而促进MDR1蛋白翻译。近来证明AEG－1作为一种RNA结合蛋白潜在影响药物的敏感性和耐药基因的表达。 AEG－1耐药性的多重功能显示，它作为抗肿瘤药物的靶点，为肿瘤靶向治疗提供新的途径是可行的。本文主要就AEG－1在化疗药物耐药方面的作用做一综述。

It has been demonstrated that astrocyte elevated gene 1 （ AEG-1 ） can promote tumor initia-tion and progression .Over expression of AEG -1 is correlated with tumor angiogenesis ,metastasis and chemother-apy resistance of tumor cells of different origins .The present article is a review on the mechanism of AEG -1 me-diated drug resistance .Studies have shown that AEG -1 participates in carcinogenesis through Ha -ras,myc,NF-κB and PI3K/Akt signalling pathways .AEG-1 can also promote autophagy through activating AMP Kinase . Other researchers demonstrate that AEG -1 promotes MDR1 protein translation by up-regulating MDR1 mRNA expression ,and thus increases polyribosome .It is testified that AEG-1 can influence drug susceptibility and ex-pression of MDR gene as a RNA binding protein .Multiple functions of AEG -1 in drug resistance in multiple cancers demonstrate that AEG -1 can be used as a novel target for antitumor drugs .