结直肠癌组织中IGFBP-3和P53的表达及临床意义

The expressions and clinical significance of IGFBP-3 and P53 in colorectal cancer

目的探讨胰岛素样生长因子结合蛋白3(IGFBP-3)、P53在结直肠癌发生发展中的作用。方法应用免疫组化SP法检测IGFBP-3、P53在138例结直肠癌和69例正常结直肠黏膜中的表达情况。结果 IGFBP-3在CRC中的阳性率显著低于对照组(P<0.05),P53在CRC中的阳性率显著高于对照组(P<0.01);IGFBP-3在CRC中的表达与组织学分级、TNM分期、淋巴结转移的表达有关(P>0.05);P53在CRC中的表达与结直肠癌TNM分期、淋巴结转移、远处转移有关(P>0.05),二者与其他因素均无关(P>0.05)。IGFBP-3与P53的表达呈负相关性(r=-0.27,P<0.01)。结论 IGFBP-3与P53可能均参与了CRC的侵袭、转移过程,且二者起到了协同作用,联合检测二者在CRC中表达对预测预后具有重要意义。

Objective To investigate the role and clinical significance of IGFBP-3 and P53 in pathogenesis of colorectal cancer （CRC）.Methods The expressions of IGFBP-3 and P53 were detected in 138 cases of colorectal cancer tissues and 69 cases of normal colorectal mucosa tissues （ control group ） by immunohistochemistry （ SP ） .Results The positive expression rate （76.8%） of IGFBP-3 in CRC was significantly lower than that （91.3%） in control group （ P 〈0.05）,however,the positive expression rate （53.6%） of P53 in CRC was significantly higher than that （2.9%） in control group （ P 〈0.05）.The expression of IGFBP-3 in CRC was correlated to histological grade,TNM stage and lymph node metastasis （ P 〈0.05 ）;the expression of P53 in CRC was correlated to TNM stage, lymph node metastasis and distant metastasis （ P 〈0.05）,but both IGFBP-3 and P53 were not related with the other factors （ P 〉0.05）.Moreover the expression of IGFBP-3 was negatively correlated to that of P53 （ r =-0.27, P 〈0.01）.Conclusion IGFBP-3 and P53 may participate in the invasion and metastasis of CRC,and the two factors have a synergistic effect,combined detection of their expressions in CRC plays an important role in predicting patient’ s prognosis.