LEEP刀联合干扰素栓治疗CIN Ⅰ合并HPV感染的疗效分析

Therapeutic effect of loop electrosurgical excision procedure combined with interferon suppository on cervical intraepithelial neoplasia Ⅰ with HPV infection

目的探讨宫颈环形电切术(LEEP)联合重组人干扰素α-2b栓(辛复宁)治疗CINⅠ合并高危型HPV感染的疗效。方法对143例经阴道镜下活检确诊为CINⅠ并伴有高危型HPV感染患者进行了回顾性分析,A组15例未给予任何治疗,B组51例给予LEEP治疗,C治疗组77例给予LEEP联合辛复宁治疗。观察3组患者术后6个月宫颈病变病理及HPV转归情况。结果 B组与C组宫颈病变转阴率及HPV转阴率均明显高于A组(P<0.05),但B、C组比较差异无统计学意义(P>0.05)。按HPV病毒载量高低分为高中低三等级,在低和中载量等级中3组HPV转阴率差异无统计学意义(P>0.05);在高载量等级中B组及C组病变HPV转阴率均高于A组(P<0.05),而2组比较差异无统计学意义(P>0.05)。结论 LEEP治疗可明显改善宫颈低度病变的病变程度及HPV转归,但联合用药后并不提高两者的转阴率。

Objective To investigate the therapeutic effect of loop electrosurgical excision procedure （ LEEP ） combined with interferon suppository on cervical intraepithelial neoplasiaⅠ（ CINⅠ） complicated by high risk human papillomavirus （ HR-HPV） infection.Metho ds The data about 143 patients with CINⅠcomplicated by HR-HPV infection were retrospectively analyzed,who were diagnosed by colposcopic biopsy,in which 15 cases were not treated （group A）,54 cases were treated by LEEP （ group B） ,77 cases were treated by LEEP combined with interferon suppository （ group C） .The pathological changes of cervical lesion and negative conversion rates of HPV infection were observed at 6 months after operation for the patients in three groups.Results The negative conversion rate of cervical lesion and negative conversion rates of HPV in group B and group C were significantly higher than those in group A （ P 〈0.05）,however,there were no significant differences between group B and group C （ P 〉0.05）.The three groups were subdivided into three grades according to HPV virus load.In low virus load and medium virus load,there were no significant differences in negative conversion rates of HPV among the three groups （ P 〉0.05） ,however,in high virus load,the negative conversion rates of HPV in group B and group C were significantly higher than those in group A （ P 〈0.05）,however,there were no significant differences in negative conversion rates of HPV between group B and group C （ P 〉0.05）.Conclusion LEEP therapy can obviously improve the pathological changes degree of cervical lesion and can increase negative conversion rates of HPV infection,but LEEP combined with interferon suppository can not enhance the negative conversion rates of HPV.