风池穴对偏头痛模型大鼠脑膜中动脉肌浆球蛋白轻链激酶表达的影响

Effect of Fengchi Point on the Expression of Myosin Light Chain Kinase on Middle Meningeal Artery of Migraine Model rats

目的:研究探讨针刺风池穴对偏头痛模型大鼠脑膜中动脉肌球蛋白轻链激酶(myosin light chain kinase,MLCK)表达的影响。方法:通过电刺激诱发法复制偏头痛动物模型,观察肌浆球蛋白轻链激酶的结构蛋白表达。结果:成功建立偏头痛大鼠模型,经统计分析,空白对照组MLCK表达比正常对照组明显减少(P<0.01),针刺风池组与风池预防组比较,无明显差异(P>0.05),但针刺风池组与空白对照组比较,风池预防组与空白对照组,均有显著差异(P<0.05)。结论:偏头痛急性发作可能与降钙素基因相关肽(Calcitonin Gene Related Pepitde,CGRP)信号系统中的MLCK表达减少有关,针刺风池穴对脑膜中动脉MLCK的表达有干预增多作用,对偏头痛急性发作有预防和治疗作用。

Objective：To study the effect of acupture of Fengchi point on the expression of myosin light chain kinase （ MLCK） in middle meningeal artery of migraine model rats.Methods： Evoked by electrical stimulation induced mi-graine animal models, detect the expression of the MLCK in middle meningeal artery.Results：The models of migraine rats were established successfully.Through statistical analysis of the blank control group being compared with the control group, MLCK expression decreased obviously （P〈0.01）;Fengchi acupuncture group compared with Fengchi preven-tion group,there was no significant difference （ P〉0.05） , but Fengchi acupuncture group compared with the blank con-trol group,Fengchi prevention group compared with the blank control group,there were all significant differences （ P〈0.05 ） .Conclusion：Possibly there is a relationship between acute attack of migraine and the decrease of MLCK of calci-tonin gene related pepitde （CGRP） signal system,and the expression of MLCK by acupuncturing Fengchi point in the middle meningeal artery is increased,and it has the preventive and curative effect acute attack of migraine.