2,6,6-三甲基-双环[3,1,1]庚基-3-(4-芳基-2-噻唑)腙类化合物的合成及其抑菌和抗肿瘤活性研究

Synthesis and Antibacterial, Antitumor Activity of 2,6,6-Thrimethylbicyclo[3,1,1]heptan-3-(4-aryl-2-thiazoyl)hydrazones

以α-蒎烯为起始原料，经加成、氧化、缩合制得中间体，继而与α-溴代芳基乙酮任常温下反应合成12个新型2,6，6-三甲基双环[3，1，1]庚基-3-（4-芳基-2-噻唑）腙类化合物，产率达52．4％~88．9％．其结构经^1H NMR，^13C NMR，IR，LC／MS和元素分析进行了确证．初步生物活性测试结果表明：部分目标化合物具有较好的抑菌活性和一定的抗肿瘤活性．

Twelve new 2,6,6-thrimethyl-bicyclo[3,1,1]heptan-3-（4-aryl-2-thiazoyl）hydrazones were synthesized by using α-pinene as starting material in four steps reaction including addition, oxidation, condensation, and reaction with α-bromo- acetophenone under room temperature. The yields of products were in the range from 52.4% to 88.9%. All synthesized new compounds were confirmed by ^1H NMR, ^13C NMR, IR, LC/MS spectra and elemental analysis. The preliminary bioassay showed that some of the target compounds exhibited significant antibacterial activity and certain antitumor activity.