一种新颖的构建(E)-3-芳氧基丙烯酸酯衍生物的方法

A Novel Construction Method for(E)-3-Aryloxyacrylate Derivatives

以炔酸酯和酚类化合物为原料,N,N-二甲基甲酰胺(DMF)为溶剂,Cu O/CH3ONa为促进体系,经过分子间的加成和自由基反应,成功地构建出了(E)-3-芳氧基丙烯酸酯衍生物.采用IR,1H NMR,13C NMR和元素分析对目标产物进行了表征.研究表明该方法具有原料便宜易得、后处理操作简单和产品纯度高等优点.

This paper reports a novel intermolecular addition and free radical homolytic reaction for the synthesis of （E）-3-aryloxyacrylate derivatives from alkynoates and phenols using N,N-dimethylformamide （DMF） as the solvent and CuO/CH3ONa as the system of promotion. The structures of product were confirmed by IR, 1H NMR, 13C NMR and elemental analysis. The results showed that this synthetic route had the advantages of easy-obtained raw materials, simple work-up and high purity product.