摘要
雷公藤化学成分复杂,为调研和概述雷公藤中主要已知单体成分的抗炎免疫调节活性和毒性以及药动学研究进展。作者检索了国内外近30年来关于雷公藤及雷公藤中单体成分药理学、毒理学和药代动力学研究的相关文献。研究证明雷公藤甲素等10多个成分具有抗炎和免疫调节作用。雷醇内酯、雷公藤碱戊、雷公藤内酯酮、去甲泽拉木醛更具有进一步药理学和毒理学研究的价值。
Tripterygium wilfordii has complex chemical components. To study and summarize the advance in studies on the anti-inflammatory and immunoregulatory activities and toxicology of known monomers of T. wilfordii, the pertinent literatures related to the studies on the pharmaeology, toxicology and pharmacokinetics of T. wilfordii over past 30 years were searched. According to the findings, more than ten anti-inflammatory and immunoregulatory monomers were found in T. wilfordii. The pharmacology and toxicology of wilfofidine, tfiotolidenol, triotonide, demethvlzevlasteral shall h,~ fi^rth^r ~t,,A;,~A
出处
《中国中药杂志》
CAS
CSCD
北大核心
2014年第21期4159-4164,共6页
China Journal of Chinese Materia Medica
关键词
雷公藤
抗炎
免疫调节
毒性
药代动力学
Tripterygium wilfordii
anti-inflammation
immunoregulation
toxicity
pharmacokinetics
