红大戟中的蒽醌和三萜类化学成分

Anthraquinones and triterpenoids from roots of Knoxia roxburghii

运用硅胶、MCI、Sephadex LH-20柱色谱及半制备型HPLC等色谱方法,从红大戟95%乙醇提取物中分离得到9个化合物,通过理化性质和NMR、MS等波谱数据鉴定化合物的结构为1,3-二羟基-2-羧基-9,10-蒽醌（1）,1-甲氧基-3,6-二羟基-2-羟甲基-9,10-蒽醌（2）,1,2,3-三羟基-9,10-蒽醌（3）,阿江榄仁酸（4）,2α,3β,24-三羟基齐墩果-12-烯-28-酸（5）,2α,3β,19α,24-四羟基乌苏-12-烯-28-酸（6）,2α,3β,24-三羟基乌苏酸（7）,2α,3β,23-三羟基乌苏-12-烯-28-酸（8）和胡萝卜苷（9）。化合物1~9均为首次从该属植物中分离得到。

Nine compounds were isolated from an ethanol extract of the roots of K. roxburghii by using a combination of various chromatographic techniques including column chromatography over silica gel, MCI gel, Sephadex LH-20, and reversed-phase HPLC. On the basis of physical-chemical properties and spectroscopic data analysis, their structures were identified as munjistin （ 1）, 1-methoxy-3,6 -dihydroxy-2 -hydroxymethyl-9,10-anthraquinone （2）, 1,2,3-trihydroxy-9,10 -anthraquinone （ 3 ）, arjunolic acid （4）, hyptatic acid -A （5）, hyptatic acid -B （ 6）, 2α, 3β, 24 -trihydroxyurs-12-en-28-oic acid （ 7）, 2α, 3β, 23-trihydroxyurs -12-en-28-oic acid （8）, and daucosterol（9）. Compounds 1-9 were obtained from this genus for the first time.