静态生活方式与代谢综合征及2型糖尿病患病的相关性研究

Association between sedentary life style and risks of metabolic syndrome and diabetes mellitus type 2

目的 探讨静态生活方式和静坐时间对MS及T2DM的影响.方法 采用多阶段分层整群抽样的方法,2010-2011年对福建省6 016名≥18岁常住居民进行人口学信息及身体活动状况等问卷调查,同时测量身高、体重、WC和血压并检测血糖、血脂,依据2005年国际糖尿病联盟（IDF）MS诊断标准和1999年WHO糖尿病诊断标准进行MS及T2DM病例诊断,并应用logistic回归分析静态生活方式与MS及T2DM的相关性.结果 福建省≥18岁人群MS及T2DM患病率分别为19.0％及8.0％,完全静坐行为的比例为18.1％,每日平均静坐时间为4.3h,对照组（C）、单纯MS组（M）、单纯糖尿病组（T）、糖尿病合并MS组（MT）静坐行为比例不同,差异有统计学意义（P＜0.001）.经年龄、性别、吸烟、饮酒、BMI、文化程度、职业和完全静坐/静坐时间校正后,与静坐时间＜2.0 h/d组相比,2.0～3.5 h/d组与MT组患病显著相关（OR=1.44,95％CI：1.03～ 2.03,P＜0.05）,3.5 ～ 6.0 h/d组及≥6.0 h/d组与M、T及MT组患病均显著相关（OR值分别为1.49～ 1.76及1.28 ～ 1.58,95％CI分别为1.19 ～ 2.45及1.02 ～ 2.23,P＜0.05）,完全静坐行为与MT组（OR=1.82,95％CI：1.33～ 2.48,P＜0.01）及M组（OR=1.43,95％CI：1.14～1.78,P＜0.01）患病风险存在独立的关联.结论 静坐生活方式与MS及T2DM患病风险可能存在相关,但仍需进一步在纵向研究中加以证实.

Objective To explore the association of sedentary life style with risk of metabolic syndrome （MS） and diabetes mellitus type 2 （T2DM）.Methods A total of 6 016 local residents aged 18 years or older in Fujian province were recruited by multi-stage stratified cluster sampling method in 2010-2011.Data,including demographic information,physical activity and sedentary time were collected.Indices related to height,weight,waist circumference,blood pressure and blood lipid were determined while MS and T2DM were diagnosed by IDF （2005） and WHO （1999） criteria.Logistic regression was used to estimate the correlations between sedentary behavior and MS or T2DM.Results The prevalence rates of MS and T2DM were 19.0% and 8.0% respectively,in local residents aged 18 years or older,in Fujian province.The overall rate of sedentary behavior was 18.1%,with the mean sedentary time as 4.3 hours.Both data showed significantly differences （P〈0.001） among control group,MS without T2DM group,MS with T2DM group and T2DM without MS group.Compared with the group of sedentary time 〈2.0 h/d,1） the group with 2.0-3.5 h/d was significantly correlated with MT group （OR=1.44,95% CI：1.03-2.03,P〈0.05）,2） groups of 3.5-6.0 h/d and ≥6.0 h/d were significantly correlated with M,T,MT group,respectively （OR：1.49-1.76 and 1.28-1.58 respectively,95% CI：1.19-2.45 and 1.02-2.23 respectively,P〈 0.05）,and 3） sedentary behavior was independently associated with an increased risk of MT group （OR=1.82,95% CI：1.33-2.48,P〈0.01） and M group （OR=1.43,95%CI：1.14-1.78,P〈0.01）,after the adjustment for factors as age,sex,cigarette smoking,alcohol drinking,BMI,education,occupation,sedentary behavior/sedentary time.Conclusion MS and T2DM were associated with sedentary lifestyle,but these findings should be confirmed through further longitudinal studies.