高迁移率族蛋白B1与牙周病及糖尿病伴牙周病关系研究进展

Recent research progress of the correlation between HMGB1 and periodontal disease,HMGB1 and diabetes-associated periodontitis

高迁移率族蛋白B1(high mobility group box 1 protein,HMGB1)作为高迁移率族蛋白(high mobility group protein,HMG)家族成员,是一种含量极为丰富的细胞核内非组蛋白。研究发现,其作为一种晚期炎性介质,在牙周病及糖尿病伴牙周病的发生发展过程起到重要作用。本文就HMGB1的生物学特性及其与牙周病、糖尿病伴牙周病等的关系研究进展做一综述。

High mobility group box 1 （HMGB1） as a member of high mobility group protein （HMG） family is one of the most abundant nuclear non-histone proteins. Recent studies have suggested that HMGB1 as a late inflammatory mediator plays a critical role in the occurrence and progression of periodontal disease and diabetes-associated periodontitis. This article will review the biological characteristics of HMGB1 and research status of relationship between HMGB1 and periodontal disease, HMGB1 and diabetes-associated periodontitis.