老年非酒精性脂肪肝与载脂蛋白B的相关性分析

Research on the relations between nonalcoholic fatty liver disease and apolipoprotein B in elderly population

目的分析中老年人非酒精性脂肪肝(NAFLD)与载脂蛋白B(ApoB)的相关性。方法我院体检中心411例中老年人(>50岁)经B超筛查分为NAFLD组和对照组。两组人群均记录相关病史,测量身高、体质量、腰围、臀围、血压,采血检测空腹血糖、血脂等生化指标,并检测75g葡萄糖负荷后2h血糖,计算体质量指数(BMI)、腰臀比(WHR);采用多元Logistic回归分析NAFLD与ApoB的相关性。结果 1)NAFLD组BMI、WHR、收缩压(SBP)、舒张压(DBP)、ALT、AST、UA、UN、Cr、FBG、P2hBG、TG、ApoB水平明显高于对照组(P<0.05),高血压、糖尿病及代谢综合征的检出率也明显高于对照组(P<0.001);而HDL-C、ApoA水平低于对照组(P<0.05)。2)多元线性回归分析显示,NAFLD与ApoB呈独立正相关(r=0.321,P<0.05)。结论中老年人群体检发现NAFLD后应据情干预血脂,以预防动脉粥样硬化和心脑血管事件发生。

Objective To explore the relationship between nonalcoholic fatty liver disease（NAFLD）and apolipoprotein B（ApoB）in elderly population.Methods A total of 411 population were divided into two groups：NAFLD group and without NAFLD group,matched for sex,age.A medical history,anthropometrics and laboratory parameters were performed for each participant.The correlations between ApoB and NAFLD was determined using multiple linear regression analysis.ResultsPeople with NAFLD had higher body mass index,waist-to-hip ratio,systolic blood pressure,diastolic blood pressure,ALT,AST,UA,UN,Cr,FBG,P2 hBG,TG and ApoB than people without NAFLD（P〈0.05）.However,people with NAFLD had lower high density lipoprotein cholesterol and APO-A（P〈0.05）.The incidences of hypertension,diabetes and metabolic syndrome in NFALD group were higher（P〈0.001）.By multiple linear regression analysis,ApoB were independently associated with NAFLD（r=0.321,P〈0.05）after adjustment for all potential confounders.Conclusion These results suggest that NAFLD is associated with ApoB independently of multiple metabolic abnormalities.Senile people with NAFLD should receive intervention in blood lipid to prevent cardiovascular events.