医院感染金黄色葡萄球菌耐药性分析

Drug resistance of Staphylococcus aureus causing nosocomial infection

目的：了解2010年1月-2012年12月金黄色葡萄球菌分布及耐药性，为临床对金黄色葡萄球菌的认识和合理使用抗菌药物提供参考。方法对来自医院2010年1月1日-2012年12月31日临床以及门诊送检的阳性标本，应用MicroScanWalkAway-96鉴定临床送检标本检出金黄色葡萄球菌，药敏试验采用K-B法进行，最终结果采用WHONET5．5软件进行分析。结果2010年1月-2012年12月3年共监测金黄色葡萄球菌876株，住院患者所占比例高，＞95．00％；金黄色葡萄球菌对青霉素3年耐药率为95．8％～97．8％；对替考拉宁、替加环素、利奈唑胺、万古霉素的敏感率均为100．00％。结论3年医院金黄色葡萄球菌检出耐药率一直比较稳定，但医院感染风险一直长期存在，只有通过多部门有效合作，才能将感染风险降到最低。

OBJECTIVE To understand the distribution and drug resistance of Staphylococcus aureus strains isolated from Jan 2010 to Dec 2012 so as to provide guidance for awareness of the S .aureus as well as the reasonable use of antibiotics .METHODS The submitted specimens were collected from the clinical and outpatient departments from Jan 1 ,2010 to Dec 31 ,2012 ,then the S .aureus strains isolated from the submitted specimens were identified by u-sing MicroScan WalkAway-96 ,the drug susceptibility testing was performed with the use of K-B method ,and the final results were analyzed by means of WHONET 5 .5 software .RESULTS From Jan 2010 to Dec 2012 ,totally 876 strains of S .aureus have been monitored in the three years ,more than 95 .00% of which were isolated from the hospitalized patients .In the three years ,the drug resistance rate of the S .aureus to penicillin varied from 95 .8%to 97 .8% ;the drug susceptibility rates to teicoplanin ,tigecycline ,linezolid ,and vancomycin were 100 .00% . CONCLUSION The drug resistance rate of the isolated S .aureus strains remains stable in the three years ,howev-er ,the risk of nosocomial infections exists for a long period of time .The risk of infections can be minimized through effective multisectoral cooperation .