应用抗菌药物预防血管介入治疗患者感染的临床研究

Clinical significance of use of antibiotics in prevention of infections in patients undergoing endovascular intervention therapy

目的探讨血管介入治疗患者应用抗菌药物预防感染的临床意义。方法选取2011年4月-2013年6月在医院进行血管介入治疗的患者86例,按照随机数字表法及介入治疗的先后顺序分为两组,每组各43例;观察组患者预防性应用抗菌药物,对照组患者未预防性应用抗菌药物,两组患者临床资料对比差异无统计学意义,具有可比性。结果观察组患者在介入治疗后发热、中性粒细胞增多、发热+中性粒细胞增多、C-反应蛋白>300mg/L等指标均低于对照组,但差异无统计学意义;两组患者均无靶器官与介入穿刺部位感染,对照组有2例患者发生败血症,发生率为4.67%;观察组患者有1例发生败血症,发生率为2.33%,两组比较差异无统计学意义。结论抗菌药物应用预防血管介入治疗患者感染的发生无显著的相关性,故介入治疗后无需应用抗菌药物。

OBJECTIVE To explore the clinical significance of use of antibiotics in prevention of infections in the patients undergoing endovascular intervention therapy .METHODS A total of 86 patients who underwent the endovascular intervention therapy in the hospital from Apr 2011 to Jun 2013 were enrolled in the study and divided into two groups according to the randomized number table method and the order of interventional therapy ,with 43 cases in each ;the patients in the observation group were treated with the prophylactic antibiotics ,while the patients in the control group were not treated with the prophylactic antibiotics ;as compared with the clinical data of the two groups of patients , there was no statistically significant difference , and they were comparable . RESULTS After the interventional therapy ,the indicators of the observation group such as fever ,neutrophilia , fever plus neutrophilia ,and C-reactive protein more than 300 mg/L were lower than those of the control group , there was no statistically significant difference .The target organ infection and the interventional puncture site infection occurred in neither of the two groups ;the septicemia occurred in 2 cases in the control group ,with the incidence rate of 4 .67% ,1 case in the observation group ,with the incidence rate of 2 .33% ,and there was no statistically significant difference .CONCLUSION The use of antibiotics is not obviously associated with the prevention of infections in the patients undergoing the endovascular intervention therapy ,thus ,it is not necessary to used antibiotics after the interventional therapy .