摘要
目的对妊娠合并高血压孕妇血清NT-pro BNP浓度进行检测,探讨NT-pro BNP的水平与妊娠高血压病之间的关联,及NT-pro BNP浓度对心功能的预测能力。方法运用电化学免疫发光技术检测121例妊娠高血压病的孕妇在早期妊娠、晚期妊娠和产后8周的NT-pro BNP的动态变化。运用彩色超声心动图方法评价孕妇的左室舒张功能。分析NT-pro BNP与妊娠过程中不良心脏事件发生的相关性。结果 (1)NT-pro BNP浓度与妊娠高血压病的严重程度密切相关,随着妊娠进程患病组的NT-pro BNP浓度逐渐增高,在妊娠晚期达到高峰。(2)妊娠高血压病患者的NT-pro BNP浓度与多数心功能呈正相关,但与EVTI呈负相关。(3)妊娠高血压病患者的NTpro BNP浓度与孕妇发生不良心脏事件成正相关。结论 NT-pro BNP可以作为反映妊娠高血压患者心功能的敏感指标,可为临床监测和干预提供依据。
Objective To detect the serum NT-proBNP concentrations of the pregnant women with gestational hyper- tension, and to explore the relationship between the NT-proBNP level and gestational hypertension and discuss the predictive ability of NT-proBNP concentration for cardiac function. Methods The electrochemical luminescent im- munoassay was used to detect the dynamic changes of 121 pregnant women with gestational hypertension in the early pregnant stage, late pregnant stage and 8th week after labor. The color ultrasound echocardiography was used to evalu- ate the pregnant women＇s left ventricular diastolic function. The relationship between NT-proBNP and occurrence of adverse cardiac incidents during pregnancy was analyzed. Results （1）The NT-proBNP concentration was closely relat- ed to the severity of gestational hypertension; As pregnancy proceed, the NT-proBNP concentration of the disease group rose gradually and reached peak at the late pregnant stage. （2）The NT-proBNP concentration of the patients with gesta- tional hypertension was positively related to the most cardiac function, but had a negative correlation with EVTI. （3） The NT-proBNP concentration of the patients with gestational hypertension was positively related to the occurrence of adverse cardiac function. Conclusion NT-proBNP concentration can be used as a sensitive indicator of the cardiac function of patients with gestational hypertension and can provide reference for clinical monitoring and intervention.
出处
《中国现代医生》
2014年第31期8-11,共4页
China Modern Doctor
基金
浙江省医药卫生科技计划项目(2011KYA163)
