双歧杆菌三联活菌胶囊对肝硬化自发性腹膜炎患者血浆炎症因子的影响及疗效观察

Influence and curative effect observation of bifid triple viable capsules on plasma inflammatory cytokines of patients with liver cirrhosis spontaneous bacterial peritonitis(SBP)

目的探讨双歧杆菌三联活菌胶囊对肝硬化自发性腹膜炎(SBP)患者血浆炎症因子的影响及疗效。方法选取乙肝后肝硬化SBP患者84例,分为观察组和对照组。两组均予以保肝、利尿降门脉压、抗生素、补充白蛋白和营养支持等治疗。观察组加用双歧杆菌三联活菌胶囊420 mg/次,3次/d,连用4周。两组分别于治疗前后检测血清hs-CRP和TNF-α水平,并比较其疗效及不良反应。结果治疗4周后,两组血清hs-CRP和TNF-α水平均明显下降(P<0.05或P<0.01),且观察组下降幅度大于对照组(P<0.05);观察组临床总有效率为92.86%,比对照组的76.19%明显升高(χ2=4.46,P<0.05)。观察组与对照组出现不良反应4例和2例,症状较轻,两组患者不良反应发生率比较差异无统计学意义(χ2=0.18,P>0.05)。结论双歧杆菌三联活菌胶囊用于肝硬化SBP患者治疗中取得了较好疗效,安全性较好,能降低血清hs-CRP和TNF-α水平,抑制局部炎症反应过程。

Objective To discuss influence and curative effect observation of bifid triple viable capsules on plasma in- flammatory cytokines of patients with liver cirrhosis spontaneous bacterial peritonitis （SBP）. Methods A total of 84 cases of patients with liver cirrhosis SBP after suffering hepatitis B were selected, and were divided into observation group and control group with 42 cases of patients in each group. The patients in two groups were given routine medical treat- merit, such as routine liver protection, diuretic decreasing portal vein pressure, antibiotics, supplement of protein, nutri- tion support and etc. The patients in observation group were additionally given 420 mg Bifid Triple Viable Capsules per time, three times a day for 4 weeks. The changes of serum hs-CRP and TNF-ot levels of patients in two groups before and after medical treatment were tested, and the clinical curative effect and adverse reaction was compared as well. Results After 4 weeks＇ medical treatment, serum hs-CRP and TNF-α levels of patients in two groups obviously de- clined （P〈0.05 or P〈0.01）, and the declining rate of patients in observation group was much higher than that in control group （P〈0.05）. Meanwhile, the total clinical efficiency of patients in observation group was 92.86%, which was much higher than that in control group （76.19%） （X2=4.46, P〈0.05）. 4 and 2 cases of adverse reaction were appeared in observation group and control group respectivety during treatment with light symptom. There were no obvious different of adverse reaction in two groups（X2=0.18 ,P〉0.05）. Conclusion Bifid Triple Viable Capsules has favorable curative ef- fect and better safety on patients with liver cirrhosis SBP, which can reduce the serum hs-CRP and TNF-ot levels and inhibit the local inflammatory process.