抑郁症患者外周血T淋巴细胞亚群、红细胞免疫及血浆游离氨基酸的变化研究

Study on Changes of Peripheral Blood T Lymphocyte Subsets,Erythrocyte Immune and Plasma Free Amino Acid in Depression Patients

目的研究并观察抑郁症患者外周血T淋巴细胞亚群、红细胞免疫及血浆游离氨基酸的变化情况。方法选取2011年10月-2014年1月本院收治的75例抑郁症患者为观察组,并以同期同龄的75名健康体检者为对照组,然后分别检测两组外周血T淋巴细胞亚群、红细胞免疫及血浆游离氨基酸水平,比较不同抑郁程度患者的检测结果。结果观察组外周血T淋巴细胞亚群及红细胞免疫指标均明显低于对照组,而多项血浆游离氨基酸指标水平也均低于对照组,且观察组中轻度、中度及重度抑郁者的上述指标水平存在明显差异,各指标间比较差异均有统计学意义（P〈0.05）。结论抑郁症患者外周血T淋巴细胞亚群、红细胞免疫及血浆游离氨基酸的变化较大,并且不同抑郁程度患者间的差异也较明显,可作为抑郁症诊治的重要依据。

Objective To study the changes of peripheral blood T lymphocyte subsets, erythrocyte immune and plasma free amino acid in patients with depression. Methods 75 patients with depression in our hospital from October 2011 to January 2014 were selected as observation group,75 healthy persons with the same age at the same period were selected as control group. The peripheral blood T lymphocyte subsets,erythrocyte immune and plasma free amino acid levels of two groups were detected, compared and correlated to different degrees of depression. Results The peripheral blood T lymphocyte subsets and erythrocyte immune indexes of observation group were all obviously lower than those of control group, and so the were plasma free amino acid indexes. In addition, the detection indexes of observation group with mild,moderate and severe depression had obvious differences（all P〈0. 05）. Conclusion The changes of peripheral blood T lymphocyte subsets,erythrocyte immune and plasma free amino acid in patients with depression are evident, and so obvious is the difference among these patients. Therefore they can be used as the important parameters for the disease diagnosis.