自然单胎妊娠多囊卵巢综合征孕妇的围生结局被引量：2

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摘要多囊卵巢综合征（polycystic ovary syndrome，PCOS）是育龄期妇女常见的一种妇科内分泌疾病，患病率约为5%-10%。最近有荟萃分析显示，PCOS患者妊娠后产科并发征和不良新生儿结局增加。但55%-75%的PCOS患者合并不孕，需通过辅助生育技术（assisted re原productive technology，ART）受孕，ART增加不良围生结局发生风险。为此，我们选择了140例自然妊娠PCOS孕妇，对其围生结局进行了前瞻性观察研究，现报道如下。

作者严李萍

机构地区绍兴市妇幼保健院妇产科

出处《浙江医学》 CAS 2014年第17期1492-1494,共3页 Zhejiang Medical Journal

关键词多囊卵巢综合征不良围生结局单胎妊娠孕妇 PCOS 辅助生育技术内分泌疾病育龄期妇女

分类号 R711.75 [医药卫生—妇产科学]

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参考文献12

1Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Work- shop Group (2004) .Revised 2003 consensus on diagnostic crite- ria and long-term health risks related to polycystic ovary syn- drome (PCQS)[J]. Hum Reprod,2004,19(1):41-47.
2Boomsma C M, Eijkemans M J, Hughes E G, et al. A meta-analy- sis of pregnancy outcomes in women with polycystic ovary syn- drome[J]. Hum Reprod Update,2006,12:673-683.
3Jaques A M, Amor D J, Baker H W, et al. Adverse obstetric and perinatal outcomes in subfertile women conceiving without assist- ed reproductive technologies[J]. Fertil Steril,2010,94:2674-2679.
4International Association of Diabetes and Pregnancy Study Groups Consensus Panel. International association of diabetes and preg- nancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy[J]. Diabetes Care, 2010. 33:676-682.
5刘畅,张治芬.青春期多囊卵巢综合征胰岛素抵抗及其与生殖内分泌代谢异常的相关性分析[J].浙江医学,2014,36(2):108-111. 被引量：9
6Kjerulff L E, Sanchez-Ramos L, Duffy D. Pregnancy outcomes in women with polycystic ovary syndrome: a metaanalysis[J]. Am J Qbstet Gynecol,2011,204(6):558.e 1-6.
7Shevell T, Malone F D,Vidaver J, et al. Assisted reproductive tech- nology and pregnancy outcome[J]. Obstet Gynecol, 2005, 106(5 Pt 1):1039-1045.
8Schieve L A,Ferre C,Peterson H B,et aI.Perinatal outcome among singleton infants conceived through assisted reproductive tech-nology in the United States[J], Obstet Gynecot, 2004, 103(6): 1144- 1153.
9Shroff R,Syrop C H,Davis W,et aI.Risk of metabolic complications in the new PCOS phenotypes based on the Rotterdam criteria[J]. Fertil Steril,2007,88(5): 1389-1395.
10Legro R S, Bentley-Lewis R, Driscoll D, et al. Insulin resistance in the sisters of women with polycystic ovary syndrome: associa- tion with hyperandrogenemia rather than menstrual irregularity [J].Clin Endocrinol,2002,87:2128-2133.

二级参考文献10

1Azziz R. Polycystic ovary syndrome,insulin resistance and molec-ular defects of insulin signaling[J].J Clinic Endocrinal Metab,2002,(09):4085-4087.
2The Rotterdam ESHRE/ASRM-sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome[J].{H}Human Reproduction,2004,(01):19-25.
3Matthews D R,Hosker J P,Rudenski A S. Homeostasis model assessment:insulin resistance and beta-cellfunction from fasting plasma glucose and insulin concentrations in man[J].Di-abetologia,1985,(07):412-419.
4Wheeler M J. The determination of bio-available testosterone[J].{H}Annals of Clinical Biochemistry,1995,(Pt 4):345-357.
5Pusalkar M,Meherji P,Gokral J. CYP11A1 and CYP17 pro-moter polymorphisms associate with hyperandrogenemia in poly-cystic ovary syndrome[J].{H}Fertility and Sterility,2009,(02):653-659.
6Diamanti-Kandarakis E,Bergiele A. The influence of obesity on hyperandrogenism and infertility in the female[J].{H}OBESITY REVIEWS,2001,(04):231-238.
7Goldfine A B,Kahn C R. Adiponectin:linking the fat cellto insulin sensitivity[J].{H}LANCET,2003,(9394):1431-1432.
8Xita N,Georgiou I,Chatzikyriakidou A. Effect of adiponectin gene polymorphisms on circulating adiponectin and insulin resis-tance indexes in women with polycystic ovary syndrome[J].{H}Clinical Chemistry,2005,(02):416-423.
9Kubota N,Terauchi Y,Yamauchi T. Disruption of adiponectin causes insulin resistance and neointimal formation[J].{H}Journal of Biological Chemistry,2002,(29):25863-25866.
10Kel erer M,Lammers R,Fritsche A. Insulin inhibits leptin re-ceptor signal ing in HEK293 cells at the level of janus kinase-2:a potential mechanism for hyperinsulinaemia-associated leptin resistance[J].{H}DIABETOLOGIA,2001,(09):1125-1132.