2006—2013年菏泽市输入性恶性疟的临床特点与处置分析

Analysis on clinical characteristics and disposal of imported falciparum malaria in Heze City from 2006-2013

目的探讨2006—2013年25例输入性恶性疟的流行特征及临床诊断和治疗效果。方法回顾性分析恶性疟病例的流行病学资料及临床资料。结果 25例恶性疟病例均有蚊虫叮咬史和有非洲地区居留史,临床症状主要为发热、畏寒、大汗、呕吐、贫血、血小板数减少、和肝肾功能异常等。在蒿甲醚联合伯氨喹治疗后,25例恶性疟均获痊愈,无输入性恶性疟传播。结论菏泽市输入性恶性疟以有非洲旅居史,青年、中年男性为主,近年来发病有所增加;恶性疟诊断主要依靠反复外周血涂片检测;蒿甲醚联合伯氨喹治疗方案治疗效果可靠。

[Objective]To investigate the clinical features,clinical diagnosis and treatment effect of 25 cases of imported falciparum malaria from 2006-2013.[Methods]The epidemiological data and clinical data of imported falciparum malaria were retrospectively analyzed.[Results]All of 25 patients with imported falciparum malaria have been bitten by mosquito or have resided in Africa. The main clinical symptoms were fever,chills,sweating,vomiting,anemia,reduced platelet count,and abnormal liver,kidney function. After the treatment of artemether combined with primaquine,all of 25 patients were cured,and there was no imported falciparum malaria transmission.[Conclusion]The imported falciparum malaria in Heze City mainly occurs in people who have resided in Africa,most of which are the youth and the middle-aged male. The incidence of imported falciparum malaria shows a rising trend in the recent years. The diagnosis of falciparum malaria relies mainly on repeated peripheral blood smear detection. The artemether combined with primaquine is a reliable treatment scheme.