鼻咽癌患者调强放疗与常规放疗毒副反应对比研究

Comparison of the Patients with Nasopharyngealcarcinomas Receiving Conventional Radiotherapy Versus Intensity-modulated Radiothorapy

探讨鼻咽癌患者常规放射治疗(CRT)与调强放射治疗(IMRT)的疗效和常见副反应,为鼻咽癌患者放疗方法选择提供科学依据。选取2010年11月至2013年5月行CRT和IMRT的初治鼻咽癌患者共56例,比较IMRT和CRT组的急性毒性反应和晚期放射性损伤。IMRT组和CRT组在局部复发和远处转移方面,两组差异无统计学意义(P>0.05),常见急性毒性反应如:口干、吞咽疼痛、听力下降、皮肤和黏膜反应的发生率CRT组高于IMRT组,差异有统计学意义(P<0.05);晚期损伤中口干、皮肤纤维化发生、吞咽困难等方面CRT组高于IMRT组,差异有统计学意义(P<0.05),而在视力下降和脑损伤的发生等方面,两组差异无统计学意义(P>0.05)。与CRT技术相比较,IMRT技术能够有效减少急性毒副反应和晚期损伤的发生率,可提高患者生活质量(QOL)。

To investigate the difference of the nasopharyngeal carcinomas conventional radiotherapy and intensity-modulated radiotherapy common side effects and effects,the acute and late events of IMRT and conventional radiation therapy were compared.56 patients diagnosed with nasopharyngeal carcinomas were treated in our hospital between November 2010 and May 2013,they were systemically reviewed.The curative effects between CRT and IMRT had no difference.Acute reactions such as,xerostomia,odynophagia,hearing loss,skin and mucosal injury had statistically difference between RT and IMRT groups （P＜0.05）.Late reactions were significantly lower than CRT,xerostomia,skin fibrosis,dysphagia （P＜0.05）.But there was no significant difference in vision changes and the incidence of brain injury between the two groups.Compared with CRT,IMRT can reduce the incidence of acute and late toxicities injury,improving the quality of life （QOL） in patients of nasopharyngeal carcinomas.