盐酸氟西汀治疗脑卒中后抑郁的Meta分析

Meta-Analysis of Fluoxetine Treatment after Stroke Depression

目的探讨盐酸氟西汀治疗脑卒中后抑郁的疗效。方法采用计算机检索系统对万方数据库、维普期刊以及中国期刊全文数据库、SCIE、Embase、Medline等与盐酸氟西汀治疗脑卒中后抑郁相关的随机对照试验进行检索,并对相关分析文献进行收集,自156篇相关文章中选出6篇进行随机对照试验,将采用盐酸氟西汀治疗的患者作为治疗组并进行Meta分析。结果治疗组患者取得了更加理想的临床治疗效果,两组患者治疗后汉密尔顿抑郁量表评分以及神经功能缺损评分差异均有统计学意义(P<0.05)。结论对脑卒中后抑郁患者行盐酸氟西汀治疗效果更佳。

Objective To evaluate effetiveness of fluoxetine for depression in stroke patients discussed and analyzed.Methods A computer search system WanFangDATA,VIP journals and Chinese Academic Journal, SCIE,Embase,Medline and other post-stroke depression associated with fluoxetine treatment of randomized control ed trials retrieval,and analysis of the literature related to the col ection,elect six randomized control ed trials relevant articles from 156,wil be used as a treatment for patients with fluoxetine treatment group and Meta-analysis. Results The treatment group achieved a more satisfactory clinical results,Hamilton Depression Rating Scale and neurological deficit scores were statistical y significant differences（P〈0.05）after the two groups of patients. Conclusion Datients with post-stroke depression fluoxetine treatment better.