372株流动人口结核分枝杆菌耐药结果分析

372 Strains mycobacterium tuberculosis for floating population drug resistance analysis

目的掌握廊坊市流动人口结核病细菌学耐药水平及其治疗效果。方法以廊坊市2009-2013年流动人口结核病耐药监测中经鉴定为结核分枝杆菌的372例病人为研究对象,采用比例法测定病人对异烟肼、利福平、乙胺丁醇、链霉素、卡那霉素、氧氟沙星6种药物的敏感性。结果流动人口总耐药率为55.1%(205/372),耐多药率为15.1%(56/372),广泛耐药率为1.9%(7/372);其中初治患者总耐药率为56.6%(176/311),耐多药率为11.9%(37/311),广泛耐药率为0.3%(1/311);复治患者总耐药率为47.5%(29/61),耐多药率为31.1%(19/61),广泛耐药率为9.8%(6/61)。结论廊坊市流动人口结核病耐药率较高,耐药控制工作不容忽视。

Objective To know drug - resistant level of pathogenic mycobacterium tuberculosis from the floating population in Langfang and analyze the effect of treatment. Methods Select 372 patients infected with Myco bacterium tuberculosis, identified by TB drug resistance monitoring from the floating population in Langfang during 2009 -2013, then examine separately its drug sensitivity to drugs as isoniazid, rifampicin, ethambutol, streptomycin, kanamycin, and ofloxacin by using proportion method. Results The total floating people drug resistance rate was 55. 1% （205/372）, multi drug resistant rate was 15. 1% （56/372）, widespread drug resistant rate was 1.9% （7/372） ; The above - mentioned 3 type rate correspondingly was 56.6% （ 176/ 311）, 11.9% （37/311）, 0.3% （1/311） for initial treatment patients, and 47.5% （29/61）, 31.1% （ 19/61 ）, 9. 8% （6/61） for retreatment patients. Conclusions The drug resistance rate of floating population tuberculosis patients was higher of Langfang city, strengthen the control work for drug resistance should not be ignored.