高通量测序技术用于肠道菌群结构与大肠癌发生关系的研究

Application of high-throughput sequencing on gut microbiota for the diagnosis of colorectal cancer

大肠癌是威胁人类的第三大恶性肿瘤。除了遗传因素外，肠道菌群在大肠癌发生中也起着重要作用，并逐渐成为研究热点。高通量测序技术的发展解析了在大肠癌发生中肠道菌群结构变化的规律并找到潜在致病菌。本文总结了特定肠道细菌在大肠癌发展中可能的作用及其机制，解析了肠道菌群介导大肠癌的两种发病模型，并探讨了肠道菌群的高通量测序技术用于大肠癌疾病监测的可能性。

Human colorectal cancer （ CRC ） presents a considerable disease burden worldwide.Besides the genetic factor, gut microbiota could be another important factor resulting in CRC and has become a hot research topic.Along with the increasing accessibility of high-throughput sequencing, the role of structure of microbiota and potential pathogens in colorectal carcinogenesis have become more and more clear.In this review, the recent insights into contributions of the microbiota and candidate CRC-potentiating species to CRC were discussed.Moreover, new findings on the role of candidate pathogens in cancer causation were highlighted.Two pathogenic models were introduced in this review.High-throughput sequencing of gut microbiota will assist us in understanding the pathogenesis of CRC, providing a theoretical basis for disease surveillance.