高压氧治疗对高血压脑出血手术患者血清CRP和TNF-α水平及预后的影响

Effects of Hyperbaric Oxygen Therapy on Levels of Serum CRP,TNF-α and Prognosis for Patients with Hypertensive Cerebral Hemorrhage Surgery

目的探讨高压氧治疗对高血压脑出血手术患者血清C-反应蛋白(CRP)和肿瘤坏死因子-α(TNF-α)水平及预后的影响。方法将60例高血压脑出血手术的患者随机分为2组,对照组术后常规治疗,高压氧组在常规治疗的基础上在术后第7天加用高压氧治疗,比较两组术前、术后17d、3个月时的CRP,TNF-α水平及疗效。结果治疗前及术后17d两组患者CRP,TNF-α水平较正常值明显升高(P<0.05),术后3个月CRP,TNF-α水平接近正常值水平(P>0.05);治疗前及治疗3个月后两组患者间CRP,TNF-α水平无差异(P>0.05),治疗17d后高压氧组CRP、TNF-α水平明显低于对照组(P<0.05)。治疗17d后两组患者间疗效无差异(P>0.05),治疗3个月后高压氧组疗效优于对照组(P<0.05)。结论高压氧治疗可快速降低高血压脑出血手术患者早期CRP,TNF-α水平并提高疗效。

Objective To explore the effects of hyperbaric oxygen （ HBO） therapy on levels of serum C-re-active protein （ CRP ） and tumor nectosis factor-α（ TNF-α） for patients with hypertensive cerebral hemorrhage surgery and prognosis .Methods Sixty patients with hypertension cerebral hemorrhage surgery were randomly divided into 2 groups ,controled group with routine treatment and HBO group with HBO therapy after a 7-day treatment on the basis of routine treatment ,compared the CRP ,TNF-αlevels and curative effects between the two groups at the time of pretreat-ment and after 17 days treatment and 3 months treatment .Results The CRP and TNF-αlevels which were before treat-ment and 17 days after treatment of two groups were obviously higher than normal （ P〈0 .05 ） , and that after 3 months were closed to normal （ P〉0 .05 ）;The levels between pretreatment and after 3-month treatment had no difference （ P〉0.05）,and these levels of HBO therapy group with 17 days treatment were significantly lower than the controled group （P〈0.05）.There were no different curative effects between two groups at the time of a 17-day treatment（P〉0.05）,when the curative effects of HBO group with a 3-month treatment was better than that of controled group （P〈0.05）.Conclu-sion HBO could quickly reduce early CRP ,TNF-αlevels of the patients with hypertension cerebral hemorrhage surgery and improve curative effects .